Rabbit polyclonal PACSIN2 antibody (A7781)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PACSIN2 antibody (A7781)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PACSIN2 antibody.

Alternative names:

Check alternative names for the antibody

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SDPII antibody
cytoplasmic phosphoprotein PACSIN2 antibody|OTTHUMP00000198281 antibody|OTTHUMP00000198282 antibody|OTTHUMP00000198283 antibody|OTTHUMP00000198284 antibody|PACN2_HUMAN antibody|Pacsin2 antibody|protein kinase C and casein kinase substrate in neurons 2 antibody|Protein kinase C and casein kinase substrate in neurons protein 2 antibody|SDPII antibody|Syndapin II antibody|Anti-PACSIN2 antibody (ab37615)

SCBT cat No: sc-390136|sc-10417|

Name

Rabbit polyclonal PACSIN2 antibody

Catalogue No.

A7781

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human PACSIN2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 56kDa/Observed: Refer to figures

Formulation

PACSIN2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PACSIN2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SDPII antibody

Database links

Human UniProt/Swiss-Prot:Q9UNF0

Protein names

SDPII

Protein function

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation. In the autoinhibited conformation, interaction with the SH3 domain inhibits membrane tubulation mediated by the F-BAR domain.Belongs to the PACSIN family.; Contains 1 F-BAR domain.; Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).

Protein cellular localization

Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection . Membrane, caveola. Note: Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.

Background

This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants.

Note

AntibodyPlus can customize PACSIN2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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