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Rabbit polyclonal PAK2 antibody (A7333)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PAK2 antibody.
Check alternative names for the antibodyExpand
PAK65 antibody, PAKgamma antibody
C-t-PAK2 antibody|CB422 antibody|EC 220.127.116.11 antibody|Gamma PAK antibody|Gamma-PAK antibody|hPAK65 antibody|Kinase antibody|p21 (CDKN1A) activated kinase 2 antibody|p21 (CDKN1A)-activated kinase 2a antibody|p21 activated kinase 2 antibody|p21 protein (Cdc42/Rac)-activated kinase 2 antibody|p21 protein Cdc42 Rac activated kinase 2 antibody|p21-activated kinase 2 antibody|p21-activated kinase, 65-KD antibody|p21-activated protein kinase I antibody|p21CDKN1A activated kinase 2 antibody|p27 antibody|p34 antibody|p58 antibody|p65PAK antibody|PAK 2 antibody|PAK-2 antibody|PAK-2p34 antibody|Pak2 antibody|PAK2_HUMAN antibody|PAK65 antibody|PAKgamma antibody|S6 H4 kinase antibody|S6/H4 kinase antibody|Serine threonine protein kinase PAK 2 antibody|Serine/threonine protein kinase PAK 2 antibody|Anti-PAK2 antibody [EP796Y] (ab76293)
SCBT cat No: sc-48826|sc-10717|sc-376010|sc-67321|sc-54758|sc-136385|sc-271066|sc-13991|sc-48349|sc-69699|sc-514908|sc-7012|sc-32281|
Rabbit polyclonal PAK2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PAK2
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 58kDa/Observed: Refer to figures
PAK2 antibody was tube-contained.
PAK2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
PAK65 antibody, PAKgamma antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.
|Protein tissue specificity|| |
Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.; Contains 1 CRIB domain.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Full length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate.; During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.; Ubiquitinated, leading to its proteasomal degradation.; PAK-2p34 is myristoylated.
|Protein cellular localization|| |
Serine/threonine-protein kinase PAK 2: Cytoplasm. Note: MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.; PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note: Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
AntibodyPlus can customize PAK2 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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