Rabbit polyclonal PAK6 antibody (A7821)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PAK6 antibody (A7821)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PAK5 antibody
CDKN1A activated kinase 6 antibody|EC 2.7.1.37 antibody|p21 activated protein kinase 6 antibody|p21 protein (Cdc42/Rac)-activated kinase 6 antibody|p21(CDKN1A) activated kinase 6 antibody|p21-activated kinase 6 antibody|p21activated kinase 6 antibody|PAK 5 antibody|PAK 6 antibody|PAK-5 antibody|PAK-6 antibody|PAK5 antibody|Pak6 antibody|PAK6_HUMAN antibody|Serine threonine protein kinase PAK 6 antibody|Serine/threonine protein kinase PAK 6 antibody|Serine/threonine protein kinase PAK6 antibody|Serine/threonine-protein kinase PAK 6 antibody|Anti-PAK6 antibody (ab37749)

SCBT cat No: sc-393102|sc-32857|sc-393075|sc-25975|

Name

Rabbit polyclonal PAK6 antibody

Catalogue No.

A7821

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PAK6

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 75kDa/Observed: Refer to figures

Formulation

PAK6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PAK6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PAK5 antibody

Database links

Human UniProt/Swiss-Prot:Q9NQU5

Protein names

PAK5

Protein function

Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Protein tissue specificity

Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.

Protein sequence and domain

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.; Contains 1 CRIB domain.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.

Protein cellular localization

Cytoplasm. Nucleus. Note: Cotranslocates into nucleus with AR in response to androgen induction.

Background

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.

Research area

All research areas>Kinases and Phosphatases>PAK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PAK6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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