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Rabbit polyclonal PAK6 antibody (A7821)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PAK6 antibody.
Check alternative names for the antibodyExpand
CDKN1A activated kinase 6 antibody|EC 22.214.171.124 antibody|p21 activated protein kinase 6 antibody|p21 protein (Cdc42/Rac)-activated kinase 6 antibody|p21(CDKN1A) activated kinase 6 antibody|p21-activated kinase 6 antibody|p21activated kinase 6 antibody|PAK 5 antibody|PAK 6 antibody|PAK-5 antibody|PAK-6 antibody|PAK5 antibody|Pak6 antibody|PAK6_HUMAN antibody|Serine threonine protein kinase PAK 6 antibody|Serine/threonine protein kinase PAK 6 antibody|Serine/threonine protein kinase PAK6 antibody|Serine/threonine-protein kinase PAK 6 antibody|Anti-PAK6 antibody (ab37749)
SCBT cat No: sc-393102|sc-32857|sc-393075|sc-25975|
Rabbit polyclonal PAK6 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PAK6
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 75kDa/Observed: Refer to figures
PAK6 antibody was tube-contained.
PAK6 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
|Protein tissue specificity|| |
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.; Contains 1 CRIB domain.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note: Cotranslocates into nucleus with AR in response to androgen induction.
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.
AntibodyPlus can customize PAK6 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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