Rabbit polyclonal PALB2 antibody (A8373)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PALB2 antibody (A8373)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FANCN antibody, PNCA3 antibody
4732427B05 antibody|BC066140 antibody|DKFZp667I166 antibody|DKFZp686E1054 antibody|FANCN antibody|FANCN GENE antibody|FLJ21816 antibody|OTTMUSP00000025884 antibody|PALB2 antibody|PALB2_HUMAN antibody|Partner and localizer of BRCA2 antibody|PNCA3 antibody|RGD1304759 antibody|Anti-PALB2 antibody (ab202970)

SCBT cat No: sc-160646|sc-160647|sc-382436|

Name

Rabbit polyclonal PALB2 antibody

Catalogue No.

A8373

Reactivity

Human

Immunogen

Recombinant protein of human PALB2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 131kDa/Observed: Refer to figures

Formulation

PALB2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PALB2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FANCN antibody, PNCA3 antibody

Database links

Human UniProt/Swiss-Prot:Q86YC2

Protein names

FANCN, PNCA3

Protein function

Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity.

Protein sequence and domain

Interaction with BRCA2 occurs through a hydrophobic pocket at the crossover between WD repeats 4 and 5.; The coiled coil domain mediates self-association.; The chromatin-association motif (ChAM) mediates association with chromatin, probably through nucleosome core particles, independently from binding to D loop, ssDNA or dsDNA structures.Contains 7 WD repeats.

Protein cellular localization

Nucleus . Note: Colocalizes with BRCA2 in nuclear foci.

Background

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Note

AntibodyPlus can customize PALB2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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