Rabbit polyclonal PARD6A antibody (A3064)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PARD6A antibody (A3064)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PAR6 antibody,PAR6C antibody,TAX40 antibody,PAR-6A antibody,TIP-40 antibody,PAR6alpha antibody
0710008C04Rik antibody|2610010A15Rik antibody|Par 6 partitioning defective 6 C elegans homolog alpha antibody|Par 6 partitioning defective 6 homolog alpha antibody|Par 6 partitioning defective 6 homolog alpha C elegans antibody|PAR 6A antibody|PAR-6 alpha antibody|PAR-6 antibody|par-6 family cell polarity regulator alpha antibody|PAR-6A antibody|PAR6 antibody|PAR6A_HUMAN antibody|PAR6alpha antibody|PAR6C antibody|Pard6a antibody|Partitioning defective 6 homolog alpha antibody|partitioning-defective protein 6 antibody|partitioning-defective protein 6, C. elegans, homolog of, alpha antibody|Tax interacting protein 40 antibody|Tax interaction protein 40 antibody|TAX40 antibody|TIP 40 antibody|TIP-40 antibody|TIP40 antibody|Anti-PAR6 antibody (ab49776)

SCBT cat No: sc-365323|sc-74479|sc-25525|sc-14401|sc-14405|sc-33898|

Name

Rabbit polyclonal PARD6A antibody

Catalogue No.

A3064

Reactivity

Human, Rat

Immunogen

A synthetic peptide of human PARD6A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

PARD6A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PARD6A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PAR6 antibody,PAR6C antibody,TAX40 antibody,PAR-6A antibody,TIP-40 antibody,PAR6alpha antibody

Database links

Human UniProt/Swiss-Prot:Q9NPB6

Protein names

PAR6,PAR6C,TAX40,PAR-6A,TIP-40,PAR6alpha

Protein function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Protein tissue specificity

Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

Protein sequence and domain

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.; The PB1 domain mediates interactions with MAP2K5.; The PDZ domain mediates the interaction with CRB3.Belongs to the PAR6 family.; Contains 1 PB1 domain.; Contains 1 PDZ (DHR) domain.; Contains 1 pseudo-CRIB domain.

Protein post-translational modifications

Phosphorylated by the TGF-beta receptor.

Protein cellular localization

Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note: Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

Background

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Note

AntibodyPlus can customize PARD6A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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