Rabbit polyclonal PARN antibody (A6941)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal PARN antibody (A6941)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PARN antibody.

Alternative names:

Check alternative names for the antibody

Expand

DAN antibody
DAN antibody|Deadenylating nuclease antibody|Deadenylation nuclease antibody|PARN antibody|PARN_HUMAN antibody|Poly A specific ribonuclease antibody|Poly(A) specific ribonuclease antibody|Poly(A)-specific ribonuclease PARN antibody|Polyadenylate specific ribonuclease antibody|Polyadenylate-specific ribonuclease antibody|Anti-PARN antibody [EPR11670(2)] (ab188333)

SCBT cat No: sc-135242|sc-47618|

Name

Rabbit polyclonal PARN antibody

Catalogue No.

A6941

Reactivity

Human

Immunogen

Recombinant protein of human PARN

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 73kDa/Observed: Refer to figures

Formulation

PARN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PARN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DAN antibody

Database links

Human UniProt/Swiss-Prot:O95453

Protein names

DAN

Protein function

3′-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3′-end poly(A) tail and the 5′-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3′-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Belongs to the CAF1 family.; Contains 1 R3H domain.

Protein post-translational modifications

Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress.

Protein cellular localization

Nucleus . Cytoplasm . Nucleus, nucleolus . Note: Some nuclear fraction is nucleolar.

Background

The protein encoded by this gene is a 3′-exoribonuclease, with similarity to the RNase D family of 3′-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize PARN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!