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Rabbit polyclonal PARN antibody (A6941)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PARN antibody.
Check alternative names for the antibodyExpand
DAN antibody|Deadenylating nuclease antibody|Deadenylation nuclease antibody|PARN antibody|PARN_HUMAN antibody|Poly A specific ribonuclease antibody|Poly(A) specific ribonuclease antibody|Poly(A)-specific ribonuclease PARN antibody|Polyadenylate specific ribonuclease antibody|Polyadenylate-specific ribonuclease antibody|Anti-PARN antibody [EPR11670(2)] (ab188333)
SCBT cat No: sc-135242|sc-47618|
Rabbit polyclonal PARN antibody
|Catalogue No.|| |
Recombinant protein of human PARN
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 73kDa/Observed: Refer to figures
PARN antibody was tube-contained.
PARN antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
3′-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3′-end poly(A) tail and the 5′-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3′-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the CAF1 family.; Contains 1 R3H domain.
|Protein post-translational modifications|| |
Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress.
|Protein cellular localization|| |
Nucleus . Cytoplasm . Nucleus, nucleolus . Note: Some nuclear fraction is nucleolar.
The protein encoded by this gene is a 3′-exoribonuclease, with similarity to the RNase D family of 3′-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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|Product type|| |
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