Rabbit polyclonal PAWR antibody (A3063)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PAWR antibody (A3063)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

PAR4 antibody, Par-4 antibody
2310001G03Rik antibody|PAR 4 antibody|PAR-4 antibody|Pawr antibody|PAWR_HUMAN antibody|PRKC Apoptosis WT1 Regulator antibody|PRKC apoptosis WT1 regulator protein antibody|Prostate apoptosis response 4 protein antibody|Prostate apoptosis response protein 4 antibody|prostate apoptosis response protein PAR-4 antibody|Transcriptional repressor Par-4-like protein PAWR antibody|Transcriptional repressor PAR4 antibody|WT1 Interacting Protein antibody|Anti-PAR4 antibody (ab5787)

SCBT cat No: sc-130078|sc-130079|sc-293206|sc-1666|sc-1249|

Name

Rabbit polyclonal PAWR antibody

Catalogue No.

A3063

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PAWR

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

PAWR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PAWR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PAR4 antibody, Par-4 antibody

Database links

Human UniProt/Swiss-Prot:Q96IZ0

Protein names

PAR4, Par-4

Protein function

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Protein tissue specificity

Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.

Protein sequence and domain

The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.; The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity).

Protein post-translational modifications

Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.

Protein cellular localization

Cytoplasm. Nucleus. Note: Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.

Background

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.

Research area

All research areas>Tumor Suppressor/Apoptosis>PAR4
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize PAWR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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