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Rabbit polyclonal PAWR antibody (A3063)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PAWR antibody.
Check alternative names for the antibodyExpand
PAR4 antibody, Par-4 antibody
2310001G03Rik antibody|PAR 4 antibody|PAR-4 antibody|Pawr antibody|PAWR_HUMAN antibody|PRKC Apoptosis WT1 Regulator antibody|PRKC apoptosis WT1 regulator protein antibody|Prostate apoptosis response 4 protein antibody|Prostate apoptosis response protein 4 antibody|prostate apoptosis response protein PAR-4 antibody|Transcriptional repressor Par-4-like protein PAWR antibody|Transcriptional repressor PAR4 antibody|WT1 Interacting Protein antibody|Anti-PAR4 antibody (ab5787)
SCBT cat No: sc-130078|sc-130079|sc-293206|sc-1666|sc-1249|
Rabbit polyclonal PAWR antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PAWR
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 37kDa/Observed: Refer to Figures
PAWR antibody was tube-contained.
PAWR antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
PAR4 antibody, Par-4 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
|Protein tissue specificity|| |
Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
|Protein sequence and domain|| |
The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.; The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity).
|Protein post-translational modifications|| |
Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note: Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.
AntibodyPlus can customize PAWR antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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