Rabbit polyclonal PAX6 antibody (A7334)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PAX6 antibody (A7334)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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AN antibody, AN2 antibody, FVH1 antibody, MGDA antibody, WAGR antibody, D11S812E antibody
AN 2 antibody|AN antibody|AN2 antibody|Aniridia type II protein antibody|D11S812E antibody|FVH1 antibody|MGC17209 antibody|MGDA antibody|Oculorhombin antibody|Paired box 6 antibody|Paired box gene 6 (aniridia keratitis) antibody|Paired Box Gene 6 antibody|Paired box homeotic gene 6 antibody|Paired box protein Pax-6 antibody|Paired box protein Pax6 antibody|PAX 6 antibody|PAX6 antibody|PAX6_HUMAN antibody|Sey antibody|WAGR antibody|Anti-PAX6 antibody (ab5790)

SCBT cat No: sc-81649|

Name

Rabbit polyclonal PAX6 antibody

Catalogue No.

A7334

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PAX6

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 47kDa/Observed: Refer to figures

Formulation

PAX6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PAX6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AN antibody, AN2 antibody, FVH1 antibody, MGDA antibody, WAGR antibody, D11S812E antibody

Database links

Human UniProt/Swiss-Prot:P26367

Protein names

AN, AN2, FVH1, MGDA, WAGR, D11S812E

Protein function

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Protein tissue specificity

Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.

Protein sequence and domain

Belongs to the paired homeobox family.; Contains 1 homeobox DNA-binding domain.; Contains 1 paired domain.

Protein post-translational modifications

Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.

Protein cellular localization

Nucleus.

Background

This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter’s anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research area

All research areas>Homeodomain Proteins>Pax
(View all antibody categories related to Homeodomain Proteins)

Note

AntibodyPlus can customize PAX6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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