Rabbit polyclonal PC antibody (A6301)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PC antibody (A6301)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

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Alternative names:

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PCB antibody
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SCBT cat No:

Name

Rabbit polyclonal PC antibody

Catalogue No.

A6301

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PC

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 129kDa/Observed: Refer to Figures

Formulation

PC antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PC antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PCB antibody

Database links

Human UniProt/Swiss-Prot:P11498

Protein names

PCB

Protein function

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.

Protein sequence and domain

Contains 1 ATP-grasp domain.; Contains 1 biotin carboxylation domain.; Contains 1 biotinyl-binding domain.; Contains 1 carboxyltransferase domain.

Protein cellular localization

Mitochondrion matrix.

Background

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5′ UTRs, but encoding the same protein, have been found for this gene.

Research area

All research areas>Synthesis and Degradation>PCB
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize PC antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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