Rabbit polyclonal PCBP2 antibody (A2531)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PCBP2 antibody (A2531)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HNRPE2 antibody, MGC110998 antibody, hnRNP-E2 antibody
Alpha CP2 antibody|Alpha-CP2 antibody|alphaCP-2 antibody|Cbp antibody|CTBP antibody|Heterogeneous nuclear ribonucleoprotein E2 antibody|Heterogenous nuclear ribonucleoprotein E2 antibody|hnRNP E2 antibody|hnRNP-E2 antibody|HNRNPE2 antibody|Hnrnpx antibody|HNRPE2 antibody|Hnrpx antibody|MGC110998 antibody|PCBP2 antibody|PCBP2_HUMAN antibody|poly(rC) binding protein 2 antibody|Poly(rC)-binding protein 2 antibody|Putative heterogeneous nuclear ribonucleoprotein X antibody|rCbinding protein 2 antibody|Anti-PCBP2/hnRNP E2 antibody [EPR14858] (ab184962)

SCBT cat No: sc-101136|sc-30724|sc-514787|sc-514975|sc-30725|

Name

Rabbit polyclonal PCBP2 antibody

Catalogue No.

A2531

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PCBP2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 39kDa/Observed: Refer to Figures

Formulation

PCBP2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PCBP2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HNRPE2 antibody, MGC110998 antibody, hnRNP-E2 antibody

Database links

Human UniProt/Swiss-Prot:Q15366

Protein names

HNRPE2, MGC110998, hnRNP-E2

Protein function

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling . It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation .; (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation . Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD .

Protein tissue specificity

Detected in all tissues examined.

Protein sequence and domain

The KH domains mediates poly(C) binding.Contains 3 KH domains.

Protein post-translational modifications

Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.; (Microbial infection) Proteolyticaly cleaved by picornavirus proteinase 3CD.

Protein cellular localization

Nucleus . Cytoplasm . Note: Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Background

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Research area

All research areas>Transcription Regulators>hnRNP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize PCBP2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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