Rabbit polyclonal PDCD4 antibody (A2570)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PDCD4 antibody (A2570)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PDCD4 antibody.

Alternative names:

Check alternative names for the antibody

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PDCD4 antibody,Protein 197/15a antibody,H731 antibody,Nuclear antigen H731 like antibody
Death up-regulated gene protein antibody|Dug antibody|H731 antibody|Ma3 antibody|MGC33046 antibody|MGC33047 antibody|Neoplastic transformation inhibitor antibody|Neoplastic transformation inhibitor protein antibody|Nuclear antigen H731 antibody|Nuclear antigen H731 like antibody|Nuclear antigen H731 like protein antibody|Nuclear antigen H731-like antibody|PDCD 4 antibody|Pdcd4 antibody|PDCD4_HUMAN antibody|Programmed cell death 4 antibody|programmed cell death 4 (neoplastic transformation inhibitor) antibody|Programmed cell death protein 4 antibody|Protein 197/15a antibody|Protein MA-3 antibody|Tis antibody|Topoisomerase-inhibitor suppressed protein antibody|Anti-PDCD4 antibody (ab51495)

SCBT cat No: sc-376430|sc-27123|sc-292504|sc-130545|

Name

Rabbit polyclonal PDCD4 antibody

Catalogue No.

A2570

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human PDCD4

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to Figures

Formulation

PDCD4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PDCD4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PDCD4 antibody,Protein 197/15a antibody,H731 antibody,Nuclear antigen H731 like antibody

Database links

Human UniProt/Swiss-Prot:Q53EL6

Protein names

PDCD4,Protein 197/15a,H731,Nuclear antigen H731 like

Protein function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

Protein tissue specificity

Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.

Protein sequence and domain

Binds EIF4A1 via both MI domains.Belongs to the PDCD4 family.; Contains 2 MI domains.

Protein post-translational modifications

Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.; Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.

Protein cellular localization

Nucleus . Cytoplasm . Note: Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 .

Background

Programmed cell death 4 (Pdcd4) is a novel tumor suppressor that inhibits translation, progression and invasion. It was first identified as being differnetially upregulated during apoptosis. Pdcd4 interferes with the activity of the eukaryotic initiation factor (eIF) 4A by displacing the scaffold protein eIF4G from its binding to the RNA helicase eIF4A.

Research area

All research areas>Tumor Suppressor/Apoptosis>Programmed Cell Death
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize PDCD4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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