Rabbit polyclonal PDE4D antibody (A1659)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PDE4D antibody (A1659)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PDE4D antibody.

Alternative names:

Check alternative names for the antibody

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DPDE3 antibody, HSPDE4D antibody, PDE4DN2 antibody, STRK1 antibody
cAMP specific 3′,5′ cyclic phosphodiesterase 4D antibody| DKFZp686M11213 antibody|5”-cyclic phosphodiesterase 4D antibody|cAMP specific phosphodiesterase 4D antibody|cAMP specific phosphodiesterase PDE4D6 antibody|cAMP-specific 3” antibody|DPDE3 antibody|Dunce like phosphodiesterase E3 antibody|FLJ97311 antibody|HSPDE4D antibody|PDE43 antibody|Pde4d antibody|PDE4D_HUMAN antibody|PDE4DN2 antibody|Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody|Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila) antibody|Phosphodiesterase 4D cAMP specific antibody|Phosphodiesterase 4D, cAMP specific (dunce) antibody|STRK1 antibody|Anti-PDE4D antibody (ab14613)

SCBT cat No: sc-25097|sc-25814|sc-25100|

Name

Rabbit polyclonal PDE4D antibody

Catalogue No.

A1659

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PDE4D

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 91kDa/Observed: Refer to Figures

Formulation

PDE4D antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PDE4D antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DPDE3 antibody, HSPDE4D antibody, PDE4DN2 antibody, STRK1 antibody

Database links

Human UniProt/Swiss-Prot:Q08499

Protein names

DPDE3, HSPDE4D, PDE4DN2, STRK1

Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Protein tissue specificity

Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.

Protein sequence and domain

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Protein post-translational modifications

Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity). Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.; Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.

Protein cellular localization

Apical cell membrane . Cytoplasm . Membrane . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note: Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells.

Background

PDE4D(cAMP-specific 3′,5′-cyclic phosphodiesterase 4D) is also named as DPDE3, PDE43 and belongs to the cyclic nucleotide phosphodiesterase family and PDE4 subfamily. PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram(PMID:16730340). It has at least 9 isoforms and all 9 PDE4D isoforms are expressed in healthy adult human hippocampus and in hippocampus from a patient with advanced Alzheimer disease(PMID:17353396). This antibody is specific to PDE4D.

Note

AntibodyPlus can customize PDE4D antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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