Rabbit polyclonal PDE5A antibody (A6831)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PDE5A antibody (A6831)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CN5A antibody, PDE5 antibody, CGB-PDE antibody
5”-cyclic phosphodiesterase antibody|CGB PDE antibody|CGB-PDE antibody|CGBPDE antibody|cGMP binding cGMP specific 3′ 5′ cyclic nucleotide phosphodiesterase antibody|cGMP binding cGMP specific 35 cyclic nucleotide phosphodiesterase antibody|cGMP binding cGMP specific phosphodiesterase antibody|cGMP binding/cGMP specific phosphodiesterase antibody|cGMP specific 3’5′ cyclic phosphodiesterase antibody|cGMP specific phosphodiesterase PDE5A2 antibody|cGMP specific phosphodiesterase type 5A antibody|cGMP-binding cGMP-specific phosphodiesterase antibody|cGMP-specific 3” antibody|CN5A antibody|CN5N antibody|PDE 5 antibody|PDE 5A antibody|PDE5 antibody|Pde5a antibody|PDE5A_HUMAN antibody|PDE5A1 antibody|Phosphodiesterase 5A antibody|Phosphodiesterase 5A cGMP specific antibody|Phosphodiesterase isozyme 5 antibody|Anti-PDE5A antibody (ab14672)

SCBT cat No: sc-398747|sc-32884|sc-30459|

Name

Rabbit polyclonal PDE5A antibody

Catalogue No.

A6831

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PDE5A

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 100kDa/Observed: Refer to figures

Formulation

PDE5A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PDE5A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CN5A antibody, PDE5 antibody, CGB-PDE antibody

Database links

Human UniProt/Swiss-Prot:O76074

Protein names

CN5A, PDE5, CGB-PDE

Protein function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5′-GMP . Specifically regulates nitric-oxide-generated cGMP .

Protein tissue specificity

Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.

Protein sequence and domain

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.Belongs to the cyclic nucleotide phosphodiesterase family.; Contains 2 GAF domains.

Protein post-translational modifications

Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1 leads to its activation.

Background

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5′-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

Note

AntibodyPlus can customize PDE5A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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