Rabbit Polyclonal PDF antibody (A10458)

$99.00$259.00

Reactivity: Human,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal PDF antibody (A10458)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal PDF antibody.

Alternative names:

Check alternative names for the antibody

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CG6496 antibody|DEFM_HUMAN antibody|mitochondrial antibody|Pdf antibody|PDF1A antibody|Peptide deformylase antibody|Peptide deformylase like protein antibody|Peptide deformylase, mitochondrial antibody|Polypeptide deformylase antibody|Anti-PDF antibody (ab76753)

SCBT cat No:

Name

Rabbit Polyclonal PDF antibody

Catalogue No.

A10458

Reactivity

Human, Rat

Immunogen

Recombinant protein of human PDF

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

27kDa

Formulation

PDF antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Removes the formyl group from the N-terminal Met of newly synthesized proteins.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Belongs to the polypeptide deformylase family.

Protein cellular localization

Mitochondrion .

Background

Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.

Note

AntibodyPlus can customize PDF antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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