Rabbit polyclonal PDGFB antibody (A1195)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PDGFB antibody (A1195)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PDGFB antibody.

Alternative names:

Check alternative names for the antibody

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PDGFB antibody,FLJ12858 antibody,PDGF2 antibody,SIS antibody,SSV antibody,c-sis antibody
Becaplermin antibody|PDGF 2 antibody|PDGF B chain antibody|PDGF subunit B antibody|PDGF-2 antibody|PDGF2 antibody|Pdgfb antibody|PDGFB_HUMAN antibody|Platelet derived growth factor 2 antibody|Platelet-derived growth factor B chain antibody|Platelet-derived growth factor beta polypeptide antibody|Platelet-derived growth factor subunit B antibody|Proto-oncogene c-Sis antibody|SIS antibody|SSV antibody|Anti-PDGF B antibody (ab23914)

SCBT cat No: sc-74494|sc-365805|sc-7878|sc-127|

Name

Rabbit polyclonal PDGFB antibody

Catalogue No.

A1195

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PDGFB

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

PDGFB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PDGFB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PDGFB antibody,FLJ12858 antibody,PDGF2 antibody,SIS antibody,SSV antibody,c-sis antibody

Database links

Human UniProt/Swiss-Prot:P01127

Protein names

PDGFB,FLJ12858,PDGF2,SIS,SSV,c-sis

Protein function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin . Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).

Protein tissue specificity

Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.

Protein sequence and domain

Belongs to the PDGF/VEGF growth factor family.

Protein cellular localization

Secreted. Note: Released by platelets upon wounding.

Background

PDGF-BB is a cystine-linked homodimer PDGF family member with key roles in development, cell proliferation, cell survival, and angiogenesis (1,2). PDGF-BB is expressed by vascular endothelium, megakaryocytes and Leydig cells (2). PDGF-BB targets pericytes, fibroblasts, monocytes and other cell types (1-3). PDGF induces fibroblast growth and migration (3) and is a chemoattractant for monocytes and granulocytes. Precursor PDGF-BB is cleaved intracellularly to generate a form that contains a carboxy-terminal stretch that serves to retain PDGF-BB in the extracellular matrix. In a second cleavage event, the carboxy-terminal stretch is removed extracellularly to generate mature PDGF-BB (1,2). PDGF-BB binds to PDGFRbeta and induces receptor dimerization. Signaling is through the PI3K/Akt, JNK, and PLCgamma pathways (1, 2). PDGF-BB may have a role in some cancer types (2).

Research area

All research areas>Growth Factors and Hormones>PDGF
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize PDGFB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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