Rabbit polyclonal PDK3 antibody (A8028)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PDK3 antibody (A8028)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CMTX6 antibody, GS1-358P8.4 antibody
[Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial antibody|[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 antibody|CMTX6 antibody|GS1-358P8.4 antibody|mitochondrial antibody|PDK3 antibody|PDK3_HUMAN antibody|Pyruvate dehydrogenase kinase isoenzyme 3 antibody|Pyruvate dehydrogenase kinase isoform 3 antibody|Pyruvate dehydrogenase kinase isozyme 3 antibody|Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial antibody|Anti-PDK3 antibody (ab154549)

SCBT cat No: sc-14490|sc-365378|sc-14488|sc-100535|

Name

Rabbit polyclonal PDK3 antibody

Catalogue No.

A8028

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PDK3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 47kDa/Observed: Refer to figures

Formulation

PDK3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PDK3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CMTX6 antibody, GS1-358P8.4 antibody

Database links

Human UniProt/Swiss-Prot:Q15120

Protein names

CMTX6, GS1-358P8.4

Protein function

Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.

Protein tissue specificity

Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain.

Protein sequence and domain

Belongs to the PDK/BCKDK protein kinase family.; Contains 1 histidine kinase domain.

Protein cellular localization

Mitochondrion matrix.

Background

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize PDK3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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