Rabbit Polyclonal PDX1 antibody (A10173)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal PDX1 antibody (A10173)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:1000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal PDX1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

GSF antibody; IPF1 antibody; IUF1 antibody; IDX-1 antibody; MODY4 antibody; PDX-1 antibody; STF-1 antibody; PAGEN1
Glucose sensitive factor antibody|Glucose-sensitive factor antibody|GSF antibody|IDX 1 antibody|IDX-1 antibody|IDX1 antibody|Insulin promoter factor 1 antibody|Insulin promoter factor 1 homeodomain transcription factor antibody|Insulin upstream factor 1 antibody|IPF 1 antibody|IPF-1 antibody|IPF1 antibody|Islet/duodenum homeobox 1 antibody|Islet/duodenum homeobox-1 antibody|IUF 1 antibody|IUF-1 antibody|IUF1 antibody|MODY4 antibody|Pancreas/duodenum homeobox 1 antibody|Pancreas/duodenum homeobox protein 1 antibody|pancreatic and duodenal homeobox P antibody|PDX 1 antibody|PDX-1 antibody|PDX1 antibody|PDX1_HUMAN antibody|Somatostatin transactivating factor 1 antibody|Somatostatin-transactivating factor 1 antibody|STF 1 antibody|STF-1 antibody|STF1 antibody|Anti-PDX1 antibody (ab47267)

SCBT cat No: sc-14664|sc-390792|sc-390808|sc-398502|sc-25403|sc-14662|

Name

Rabbit Polyclonal PDX1 antibody

Catalogue No.

A10173

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human PDX1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

31kDa

Formulation

PDX1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GSF antibody; IPF1 antibody; IUF1 antibody; IDX-1 antibody; MODY4 antibody; PDX-1 antibody; STF-1 antibody; PAGEN1

Protein names

GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1; PAGEN1

Protein function

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Protein tissue specificity

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

Protein sequence and domain

Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.; Contains 1 homeobox DNA-binding domain. The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter.; The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).

Protein post-translational modifications

Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).

Protein cellular localization

Nucleus. Cytoplasm, cytosol .

Background

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Homeodomain-Proteins/">Homeodomain Proteins</a>><a href="http://antibodyplus.com/product-tag/PDX/">PDX</a><br><a href="http://antibodyplus.com/product-tag/Homeodomain-Proteins/"&gt; (View all antibody categories related to Homeodomain Proteins)</a>

Note

AntibodyPlus can customize PDX1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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