Rabbit polyclonal PEBP1 antibody (A0578)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,RIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PEBP1 antibody (A0578)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,RIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:20 – 1:50 RIP 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PEBP1 antibody,HCNP antibody,PBP antibody,PEBP antibody,RKIP antibody
Epididymis luminal protein 210 antibody|Epididymis secretory protein Li 34 antibody|Epididymis secretory protein Li 96 antibody|HCNP antibody|HCNPpp antibody|HEL 210 antibody|HEL S 34 antibody|HEL S 96 antibody|Hippocampal cholinergic neurostimulating peptide antibody|Neuropolypeptide h3 antibody|PBP antibody|PEBP antibody|PEBP 1 antibody|PEBP-1 antibody|Pebp1 antibody|PEBP1_HUMAN antibody|Phosphatidylethanolamine binding protein antibody|Phosphatidylethanolamine binding protein 1 antibody|Prostatic binding protein antibody|Prostatic-binding protein antibody|R kip antibody|Raf kinase inhibitor protein antibody|Raf kinase inhibitory protein antibody|RKIP antibody|Anti-PBP antibody [EPR2875Y] (ab76582)

SCBT cat No: sc-376925|

Name

Rabbit polyclonal PEBP1 antibody

Catalogue No.

A0578

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PEBP1

Host

Rabbit

Applications

WB, IHC, IF, IP, RIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:20 – 1:50
RIP 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 21kDa/Observed: Refer to Figures

Formulation

PEBP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PEBP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PEBP1 antibody,HCNP antibody,PBP antibody,PEBP antibody,RKIP antibody

Database links

Human UniProt/Swiss-Prot:P30086

Protein names

PEBP1,HCNP,PBP,PEBP,RKIP

Protein function

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Protein sequence and domain

Belongs to the phosphatidylethanolamine-binding protein family.

Protein cellular localization

Cytoplasm .

Background

Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding protein (PEBP) family that associates with Raf-1 and the MEK and MAP kinases (1). RKIP has been shown to complex with Raf-1, MEK, and ERK (2). Although MEK and ERK can simultaneously bind RKIP, the association between Raf-1 and RKIP and that of RKIP and MEK are mutually exclusive. Thus, RKIP competitively disrupts the Raf-1-MEK complex and effectively terminates signal transmission from Raf-1 to MAP kinases (2). The inhibitory effect of RKIP on MAP kinase signaling is eliminated by PKC phosphorylation of RKIP at Ser153 (3). PKC phosphorylation on Ser153 also promotes the association of RKIP with GRK2, which prevents GRK2-dependent internalization of GPCR (4). RKIP also interacts with modules of the NF-kappaB pathway, including NF-kappaB-inducing kinase (NIK), TAK1, IKKalpha and IKKbeta (5). These interactions antagonize cytokine-induced activation of the NF-kappaB pathway (5). Restoration of RKIP expression is associated with the inhibition of prostate cancer metastasis, implying that RKIP may be a potential clinical target as a suppressor of tumor metastasis through inhibition of vascular invasion (6).

Research area

All research areas>Signaling Intermediates>RKIP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PEBP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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