Rabbit polyclonal PHB antibody (A0056)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PHB antibody (A0056)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

PHB antibody,PHB1 antibody
Epididymis luminal protein 215 antibody|Epididymis secretory sperm binding protein Li 54e antibody|HEL 215 antibody|HEL S 54e antibody|PHB antibody|PHB_HUMAN antibody|PHB1 antibody|Prohibitin antibody|Anti-Prohibitin antibody [EP2803Y] (ab75766)

SCBT cat No: sc-56346|

Name

Rabbit polyclonal PHB antibody

Catalogue No.

A0056

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PHB

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to Figures

Formulation

PHB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PHB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PHB antibody,PHB1 antibody

Database links

Human UniProt/Swiss-Prot:P35232

Protein names

PHB,PHB1

Protein function

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Protein tissue specificity

Widely expressed in different tissues.

Protein sequence and domain

Belongs to the prohibitin family.

Protein cellular localization

Mitochondrion inner membrane .

Background

The prohibitins, called PHB1 and PHB2, are highly conserved proteins that are present in multiple compartments in eukaryotic cells. PHB1 is 30kDa tumor suppressor protein involved in cell cycle control (1). PHB1 has been found in mitochondria, the nucleus and the plasma membrane, as well as extracellularly in circulation (2). In mitochondria prohibitins mainly exist as membrane-bound ring complexes and function as chaperones maintaining mitochondrial protein stability during protein synthesis and transportation (3,4). In the nucleus prohibitins interact with transcription factors such as Rb and p53 to regulate target gene transcription (2,5). Extracellular prohibitin can bind and activate C3 to enhance complement activation (6).

Research area

All research areas>Cell Cycle Proteins>Prohibitin
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize PHB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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