Rabbit polyclonal PHF1 antibody (A8450)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PHF1 antibody (A8450)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PHF1 antibody.

Alternative names:

Check alternative names for the antibody

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PCL1 antibody, PHF2 antibody, hPHF1 antibody, MTF2L2 antibody, TDRD19C antibody
hPCl1 antibody|MTF2 L2 antibody|MTF2L 2 antibody|MTF2L2 antibody|PCL 1 antibody|PCL1 antibody|PHD finger protein 1 antibody|PHD finger protein1 antibody|PHF 1 antibody|PHF 2 antibody|Phf1 antibody|PHF1_HUMAN antibody|PHF2 antibody|Plc 1 antibody|Plc1 antibody|Polycomb like protein 1 antibody|Polycomb like protein1 antibody|Polycomb-like protein 1 antibody|Protein PHF1 antibody|T complex testis expressed 3 antibody|T complex testis expressed3 antibody|Tctex 3 antibody|Tctex3 antibody|Anti-PHF1 antibody [EPR14222] (ab184951)

SCBT cat No: sc-130646|sc-515013|sc-98763|sc-107933|sc-101107|

Name

Rabbit polyclonal PHF1 antibody

Catalogue No.

A8450

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human PHF1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 62kDa/Observed: Refer to figures

Formulation

PHF1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PHF1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PCL1 antibody, PHF2 antibody, hPHF1 antibody, MTF2L2 antibody, TDRD19C antibody

Database links

Human UniProt/Swiss-Prot:O43189

Protein names

PCL1, PHF2, hPHF1, MTF2L2, TDRD19C

Protein function

Polycomb group (PcG) that specifically binds histone H3 trimethylated at ‘Lys-36’ (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci . According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 . Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.

Protein tissue specificity

Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney.

Protein sequence and domain

The Tudor domain recognizes and binds H3K36me3 .Belongs to the Polycomblike family.; Contains 2 PHD-type zinc fingers.; Contains 1 Tudor domain.

Protein cellular localization

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note: Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co-localizes with NEK6 in the centrosome.

Background

This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Transcription Regulators>PHF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize PHF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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