Rabbit polyclonal PHF19 antibody (A8065)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PHF19 antibody (A8065)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PHF19 antibody.

Alternative names:

Check alternative names for the antibody

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PCL3 antibody, MTF2L1 antibody, TDRD19B antibody
hPCL3 antibody|MGC131698 antibody|MGC149712 antibody|MGC149713 antibody|MGC23929 antibody|MTF2L1 antibody|OTTHUMP00000021996 antibody|OTTHUMP00000021998 antibody|PCL3 antibody|PHD finger protein 19 antibody|Phf19 antibody|PHF19 protein antibody|PHF19_HUMAN antibody|Polycomb like 3 antibody|Polycomb like protein 3 antibody|Polycomb-like protein 3 antibody|TDRD19B antibody|Tudor domain containing 19B antibody|Anti-PHF19 antibody – C-terminal (ab177518)

SCBT cat No:

Name

Rabbit polyclonal PHF19 antibody

Catalogue No.

A8065

Reactivity

Human

Immunogen

Recombinant protein of human PHF19

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 66kDa/Observed: Refer to figures

Formulation

PHF19 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PHF19 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PCL3 antibody, MTF2L1 antibody, TDRD19B antibody

Database links

Human UniProt/Swiss-Prot:Q5T6S3

Protein names

PCL3, MTF2L1, TDRD19B

Protein function

Polycomb group (PcG) that specifically binds histone H3 trimethylated at ‘Lys-36’ (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at ‘Lys-36’ (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.

Protein tissue specificity

Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma and in glioma cell lines.

Protein sequence and domain

The Tudor domain recognizes and binds H3K36me3 . May also bind H3K27me3, with a lower affinity .Belongs to the Polycomblike family.; Contains 2 PHD-type zinc fingers.; Contains 1 Tudor domain.

Protein cellular localization

Nucleus .

Note

AntibodyPlus can customize PHF19 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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