Rabbit Polyclonal PHLPP1 antibody (A9542)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal PHLPP1 antibody (A9542)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

SCOP antibody; PHLPP antibody; PLEKHE1
hSCOP antibody|KIAA0606 antibody|PH domain and leucine rich repeat protein phosphatase antibody|PH domain leucine rich repeat containing protein phosphatase antibody|PH domain leucine rich repeat protein phosphatase antibody|PH domain leucine-rich repeat-containing protein phosphatase 1 antibody|PH domain-containing family E member 1 antibody|PHLP1_HUMAN antibody|PHLPP antibody|Phlpp1 antibody|Pleckstrin homology domain containing family E (with leucine rich repeats) member 1 antibody|Pleckstrin homology domain containing family E protein 1 antibody|Pleckstrin homology domain-containing family E member 1 antibody|PLEKHE 1 protein antibody|PLEKHE1 antibody|SCN circadian oscillatory protein antibody|SCOP antibody|Suprachiasmatic nucleus circadian oscillatory protein antibody|Suprachiasmatic nucleus circadian protein antibody|Anti-PHLPP antibody (ab71972)

SCBT cat No:

Name

Rabbit Polyclonal PHLPP1 antibody

Catalogue No.

A9542

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PHLPP1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

185kDa

Formulation

PHLPP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SCOP antibody; PHLPP antibody; PLEKHE1

Protein names

SCOP; PHLPP; PLEKHE1

Protein function

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).

Protein tissue specificity

In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous tissues.

Protein sequence and domain

Contains 21 LRR (leucine-rich) repeats.; Contains 1 PH domain.; Contains 1 PPM-type phosphatase domain. The PH domain is required for interaction with PRKCB and its dephosphorylation.

Protein cellular localization

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.; Isoform 2: Cell membrane .

Background

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Note

AntibodyPlus can customize PHLPP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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