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Rabbit Polyclonal Phospho-4.1R (Y660) antibody (STJ90628)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for 4.1R (phospho Tyr660) Polyclonal Antibody.
Check alternative names for the antibodyExpand
EPB41 antibody, E41P antibody,|4.1R antibody|41_HUMAN antibody|Band 4.1 antibody|E41P antibody|EL 1 antibody|EL1 antibody|EL1 gene antibody|Elliptocytosis 1 antibody|Elliptocytosis 1 RH linked antibody|EPB 4.1 antibody|EPB 41 antibody|EPB4.1 antibody|Epb41 antibody|Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked) antibody|Erythrocyte membrane protein band 4.1 antibody|Erythrocyte surface protein band 4.1 antibody|HE antibody|P4.1 antibody|Protein 4.1 antibody|Protein 4.1, red blood cell type antibody|Anti-EPB41 antibody (ab54597)
SCBT cat No: sc-398983|sc-166759|sc-514096|sc-366179|sc-25967|sc-25968|
4.1R (phospho Tyr660) Polyclonal Antibody
|Catalogue No.|| |
Phospho-4.1R (Y660) Polyclonal Antibody detects endogenous levels of 4.1R protein only when phosphorylated at Y660.
Synthesized phospho-peptide derived from 41R (phospho Tyr660) at AA range 600-680
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
4.1R (phospho Tyr660) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
4.1R (phospho Tyr660) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Protein 4.1 antibody, P4.1 antibody, 4.1R antibody, Band 4.1 antibody, EPB4.1 antibody
|Protein names|| |
Protein 4.1 , P4.1 , 4.1R , Band 4.1 , EPB4.1
|Protein function|| |
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
|Involvement in disease|| |
Elliptocytosis 1 (EL1) [MIM:611804]: A Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 FERM domain.
|Protein post-translational modifications|| |
Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein’s functions. / Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex. / O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
|Protein cellular localization|| |
Cytoplasm > cytoskeleton / Cytoplasm > cell cortex / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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