Rabbit Polyclonal Phospho-53BP1 (S6) antibody (STJ90870)

$99.00$319.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-53BP1 (S6) antibody (STJ90870)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for 53BP1 (phospho Ser6) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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TP53BP1 antibody,|53 BP1 antibody|53BP1 antibody|FLJ41424 antibody|MGC138366 antibody|p202 antibody|p53 binding protein 1 antibody|p53 BP1 antibody|p53-binding protein 1 antibody|p53BP1 antibody|TP53 BP1 antibody|TP53B_HUMAN antibody|Tp53bp1 antibody|TRP53 BP1 antibody|Tumor protein 53 binding protein 1 antibody|Tumor protein p53 binding protein 1 antibody|Tumor suppressor p53 binding protein 1 antibody|Tumor suppressor p53-binding protein 1 antibody|Anti-53BP1 antibody (ab36823)
SCBT cat No: sc-135749|sc-135748|

 

Name

53BP1 (phospho Ser6) Polyclonal Antibody

Catalogue No.

STJ90870

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Phospho-53BP1 (S6) Polyclonal Antibody detects endogenous levels of 53BP1 protein only when phosphorylated at S6.

Immunogen

Synthesized phospho-peptide derived from 53BP1 (phospho Ser6) at AA range 1-80

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

213 kDa

Formulation

53BP1 (phospho Ser6) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

53BP1 (phospho Ser6) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tumor suppressor p53-binding protein 1 antibody, 53BP1 antibody, p53-binding protein 1 antibody, p53BP1 antibody

Database links

Human UniProt/Swiss-Prot:Q12888;Mouse UniPort/Swiss-Prot: P70399;Rat UniProt/Swiss-Port: F1M842;Human Entrez Gene: 7158;Mouse Entrez Gene: 27223;

Protein names

Tumor suppressor p53-binding protein 1 , 53BP1 , p53-binding protein 1 , p53BP1

Protein function

Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.

Involvement in disease

Note: A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. .

Protein sequence and domain

The Tudor-like region mediates binding to H4K20me2. / Contains 2 BRCT domains.

Protein post-translational modifications

Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. / Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Dephosphorylated by PPP5C.

Protein cellular localization

Nucleus / Chromosome > centromere > kinetochore

Research area

All research areas>Tumor Suppressor/Apoptosis>53bp
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize 53BP1 (phospho Ser6) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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