Rabbit Polyclonal Phospho-ACACA-S79 antibody (AP0298)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-ACACA-S79 antibody (AP0298)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ACC antibody; ACAC antibody; ACC1 antibody; ACCA antibody; ACACAD antibody;
ACAC antibody|ACACA antibody|ACACA_HUMAN antibody|ACACB antibody|ACC alpha antibody|ACC antibody|ACC beta antibody|ACC-alpha antibody|ACC1 antibody|ACC2 antibody|ACCA antibody|ACCB antibody|Acetyl CoA carboxylase 1 antibody|Acetyl CoA carboxylase 2 antibody|Acetyl CoA carboxylase alpha antibody|Acetyl CoA carboxylase beta antibody|Acetyl Coenzyme A carboxylase alpha antibody|Acetyl Coenzyme A carboxylase beta antibody|Biotin carboxylase antibody|COA1 antibody|COA2 antibody|HACC275 antibody|OTTHUMP00000164069 antibody|OTTHUMP00000164070 antibody|OTTHUMP00000164076 antibody|OTTHUMP00000240532 antibody|Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y] (ab45174)

SCBT cat No: sc-26821|sc-26820|sc-377313|sc-50387|sc-377318|

Name

Rabbit Polyclonal Phospho-ACACA-S79 antibody

Catalogue No.

AP0298

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S79 of human ACACA

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

265kDa

Formulation

Phospho-ACACA-S79 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ACC antibody; ACAC antibody; ACC1 antibody; ACCA antibody; ACACAD antibody;

Protein names

ACC; ACAC; ACC1; ACCA; ACACAD;

Protein function

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Protein tissue specificity

Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

Protein sequence and domain

Contains 1 ATP-grasp domain.; Contains 1 biotin carboxylation domain.; Contains 1 biotinyl-binding domain.; Contains 1 CoA carboxyltransferase C-terminal domain.; Contains 1 CoA carboxyltransferase N-terminal domain.

Protein post-translational modifications

Phosphorylation on Ser-1263 is required for interaction with BRCA1.

Protein cellular localization

Cytoplasm.

Background

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Synthesis-and-Degradation/">Synthesis and Degradation</a>><a href="http://antibodyplus.com/product-tag/ACC/">ACC</a><br><a href="http://antibodyplus.com/product-tag/Synthesis-and-Degradation/"&gt; (View all antibody categories related to Synthesis and Degradation)</a>

Note

AntibodyPlus can customize Phospho-ACACA-S79 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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