Rabbit polyclonal Phospho-ALK-Y1096 antibody (AP0503)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal Phospho-ALK-Y1096 antibody (AP0503)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal Phospho-ALK-Y1096 antibody.

Alternative names:

Check alternative names for the antibody

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CD246 antibody, NBLST3 antibody
Alk antibody|ALK tyrosine kinase receptor antibody|ALK/EML4 fusion gene, included antibody|ALK/NPM1 fusion gene, included antibody|ALK_HUMAN antibody|anaplastic lymphoma kinase (Ki-1) antibody|Anaplastic lymphoma kinase antibody|Anaplastic lymphoma kinase Ki1 antibody|anaplastic lymphoma receptor tyrosine kinase antibody|CD 246 antibody|CD246 antibody|CD246 antigen antibody|EC 2.7.10.1 antibody|Ki 1 antibody|Ki1 antibody|mutant anaplastic lymphoma kinase antibody|NBLST 3 antibody|NBLST3 antibody|Tcrz antibody|TFG/ALK antibody|Anti-ALK antibody [5A4] (ab17127)

SCBT cat No: sc-6343|

Name

Rabbit polyclonal Phospho-ALK-Y1096 antibody

Catalogue No.

AP0503

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding Y1096 of human ALK

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 176kDa/Observed: Refer to figures

Formulation

Phospho-ALK-Y1096 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Phospho-ALK-Y1096 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD246 antibody, NBLST3 antibody

Database links

Human UniProt/Swiss-Prot:Q9UM73

Protein names

CD246, NBLST3

Protein function

Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Protein tissue specificity

Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.; Contains 1 LDL-receptor class A domain.; Contains 2 MAM domains.; Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association.; N-glycosylated.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Note: Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.

Background

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Research area

All research areas>Membrane Receptors>ALK
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize Phospho-ALK-Y1096 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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