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Rabbit Polyclonal Phospho-ALK (Y1507) antibody (STJ90845)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for ALK (phospho Tyr1507) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ALK antibody,|Alk antibody|ALK tyrosine kinase receptor antibody|ALK/EML4 fusion gene, included antibody|ALK/NPM1 fusion gene, included antibody|ALK_HUMAN antibody|anaplastic lymphoma kinase (Ki-1) antibody|Anaplastic lymphoma kinase antibody|Anaplastic lymphoma kinase Ki1 antibody|anaplastic lymphoma receptor tyrosine kinase antibody|CD 246 antibody|CD246 antibody|CD246 antigen antibody|EC 184.108.40.206 antibody|Ki 1 antibody|Ki1 antibody|mutant anaplastic lymphoma kinase antibody|NBLST 3 antibody|NBLST3 antibody|Tcrz antibody|TFG/ALK antibody|Anti-ALK antibody [5A4] (ab17127)
SCBT cat No: sc-6343|
ALK (phospho Tyr1507) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
Phospho-ALK (Y1507) Polyclonal Antibody detects endogenous levels of ALK protein only when phosphorylated at Y1507.
Synthesized phospho-peptide derived from ALK (phospho Tyr1507) at AA range 1450-1530
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
ALK (phospho Tyr1507) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ALK (phospho Tyr1507) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ALK tyrosine kinase receptor antibody, Anaplastic lymphoma kinase antibody, CD antigen CD246 antibody
|Protein names|| |
ALK tyrosine kinase receptor , Anaplastic lymphoma kinase , CD antigen CD246
|Protein function|| |
Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Activated by ligand-binding and subsequent phosphorylation. Inactivated through dephosphorylation by receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) when there is no stimulation by a ligand. Staurosporine, crizotinib and CH5424802 act as inhibitors of ALK kinase activity.
|Protein tissue specificity|| |
Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
|Involvement in disease|| |
Note: A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.; Note: A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.; Note: A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.; Neuroblastoma 3 (NBLST3) [MIM:613014]: A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Note: The ALK signaling pathway plays an important role in glioblastoma, the most common malignant brain tumor of adults and one of the most lethal cancers. It regulates both glioblastoma migration and growth.; Note: A chromosomal aberration involving ALK is found in one subject with colorectal cancer. Translocation t(2;2)(p23.1;p23.3). A 5 million base pair tandem duplication generates an in-frame WDCP-ALK gene fusion. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. / Contains 1 LDL-receptor class A domain. / Contains 2 MAM domains. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association. / N-glycosylated.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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