Rabbit Polyclonal Phospho-ALOX5-S271 antibody (AP0573)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-ALOX5-S271 antibody (AP0573)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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5-LO antibody; 5LPG antibody; LOG5 antibody; 5-LOX antibody;
5 LO antibody|5 LOX antibody|5-lipoxygenase antibody|5-LO antibody|5-LOX antibody|5LOX antibody|5LPG antibody|ALOX 5 antibody|Alox5 antibody|Arachidonate 5 lipoxygenase antibody|Arachidonate 5-lipoxygenase antibody|arachidonic 5-lipoxygenase alpha-10 isoform antibody|arachidonic 5-lipoxygenase delta-10-13 isoform antibody|arachidonic 5-lipoxygenase delta-13 isoform antibody|arachidonic 5-lipoxygenase delta-p10 isoform antibody|Arachidonic acid 5 lipoxygenase antibody|Leukotriene A4 synthase antibody|LOG 5 antibody|LOG5 antibody|LOX5_HUMAN antibody|MGC163204 antibody|Anti-5 Lipoxygenase antibody [EP6072(2)] (ab169755)

SCBT cat No: sc-136195|sc-8886|sc-20785|sc-8885|

Name

Rabbit Polyclonal Phospho-ALOX5-S271 antibody

Catalogue No.

AP0573

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S271 of human ALOX5

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

78kDa

Formulation

Phospho-ALOX5-S271 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

5-LO antibody; 5LPG antibody; LOG5 antibody; 5-LOX antibody;

Protein names

5-LO; 5LPG; LOG5; 5-LOX;

Protein function

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Protein sequence and domain

Belongs to the lipoxygenase family.; Contains 1 lipoxygenase domain.; Contains 1 PLAT domain.

Protein post-translational modifications

Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.

Protein cellular localization

Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Background

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Synthesis-and-Degradation/">Synthesis and Degradation</a>><a href="http://antibodyplus.com/product-tag/LO/">LO</a><br><a href="http://antibodyplus.com/product-tag/Synthesis-and-Degradation/"&gt; (View all antibody categories related to Synthesis and Degradation)</a>

Note

AntibodyPlus can customize Phospho-ALOX5-S271 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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