Rabbit Polyclonal Phospho-APC (S2054) antibody (STJ90884)

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Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-APC (S2054) antibody (STJ90884)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for APC (phospho Ser2054) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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APC antibody, DP2.5 antibody,|Adenomatous Polyposis Coli antibody|Adenomatous polyposis coli protein antibody|Apc antibody|APC_HUMAN antibody|CC1 antibody|Deleted in polyposis 2.5 antibody|DP2 antibody|DP2.5 antibody|DP3 antibody|FAP antibody|FPC antibody|GS antibody|Protein APC antibody|Anti-APC antibody (ab15270)
SCBT cat No: sc-393704|sc-53165|sc-896|sc-53166|sc-9998|sc-7930|sc-895|sc-389835|

 

Name

APC (phospho Ser2054) Polyclonal Antibody

Catalogue No.

STJ90884

Reactivity

Human

Specificity

Phospho-APC (S2054) Polyclonal Antibody detects endogenous levels of APC protein only when phosphorylated at S2054.

Immunogen

Synthesized phospho-peptide derived from APC (phospho Ser2054) at AA range 1990-2070

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

311 kDa

Formulation

APC (phospho Ser2054) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

APC (phospho Ser2054) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Adenomatous polyposis coli protein antibody, Protein APC antibody, Deleted in polyposis 2.5 antibody

Database links

Human UniProt/Swiss-Prot:P25054;Rat UniProt/Swiss-Port: P70478;Human Entrez Gene: 324;Mouse Entrez Gene: 11789;Rat Entrez Gene: Rn.156346

Protein names

Adenomatous polyposis coli protein , Protein APC , Deleted in polyposis 2.5

Protein function

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Protein tissue specificity

Expressed in a variety of tissues.

Involvement in disease

Familial adenomatous polyposis (FAP) [MIM:175100]: A cancer predisposition syndrome characterized by adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract (ampullary, duodenal and gastric adenomas). This is a viciously premalignant disease with one or more polyps progressing through dysplasia to malignancy in untreated gene carriers with a median age at diagnosis of 40 years. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hereditary desmoid disease (HDD) [MIM:135290]: Autosomal dominant trait with 100% penetrance and possible variable expression among affected relatives. HDD patients show multifocal fibromatosis of the paraspinal muscles, breast, occiput, arms, lower ribs, abdominal wall, and mesentery. Desmoid tumors appears also as a complication of familial adenomatous polyposis. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Medulloblastoma (MDB) [MIM:155255]: Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. . Note: The gene represented in this entry may be involved in disease pathogenesis.; Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Note: The gene represented in this entry may be involved in disease pathogenesis.; Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note: The gene represented in this entry may be involved in disease pathogenesis.

Protein sequence and domain

The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends. / Belongs to the adenomatous polyposis coli (APC) family. / Contains 7 ARM repeats.

Protein post-translational modifications

Phosphorylated by GSK3B. / Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.

Protein cellular localization

Cell junction > adherens junction / Cytoplasm > cytoskeleton / Cell projection > lamellipodium / Cell projection > ruffle membrane / Cytoplasm / Cell membrane

Research area

All research areas>Tumor Suppressor/Apoptosis>Adenomatous Polyposis coli
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize APC (phospho Ser2054) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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