Rabbit Polyclonal Phospho-AR-beta2 (S355/S356) antibody (STJ90872)

$99.00$319.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-AR-beta2 (S355/S356) antibody (STJ90872)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for AR-beta2 (phospho Ser355/S356) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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ADRB2 antibody, ADRB2R antibody, B2AR antibody,||
SCBT cat No: To be updated

 

Name

AR-beta2 (phospho Ser355/S356) Polyclonal Antibody

Catalogue No.

STJ90872

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Phospho-AR-beta2 (S355/S356) Polyclonal Antibody detects endogenous levels of AR-beta2 protein only when phosphorylated at S355/S356.

Immunogen

Synthesized phospho-peptide derived from AR-beta2 (phospho Ser355/S356) at AA range 300-380

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

47 kDa

Formulation

AR-beta2 (phospho Ser355/S356) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

AR-beta2 (phospho Ser355/S356) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Beta-2 adrenergic receptor antibody, Beta-2 adrenoreceptor antibody, Beta-2 adrenoceptor antibody

Database links

Human UniProt/Swiss-Prot:P07550;Mouse UniPort/Swiss-Prot: P18762;Rat UniProt/Swiss-Port: Q8VBU7;Human Entrez Gene: 154;Mouse Entrez Gene: 11555;Rat Entrez Gene: Rn.10206

Protein names

Beta-2 adrenergic receptor , Beta-2 adrenoreceptor , Beta-2 adrenoceptor

Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Protein sequence and domain

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Protein post-translational modifications

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. / Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. / Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor. / Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation . Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent. / Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.

Protein cellular localization

Cell membrane / Multi-pass membrane protein / Early endosome

Research area

All research areas>Steroid Receptors>Androgen Receptor
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus can customize AR-beta2 (phospho Ser355/S356) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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