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Rabbit Polyclonal Phospho-Ataxin-1 (S776) antibody (STJ90696)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Ataxin-1 (phospho Ser776) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ATXN1 antibody, ATX1 antibody, SCA1 antibody,|alternative ataxin1 antibody|Ataxin-1 antibody|ATX1 antibody|ATX1_HUMAN antibody|Atxn1 antibody|D6S504E antibody|OTTHUMP00000016065 antibody|SCA1 antibody|Spinocerebellar ataxia type 1 protein antibody|Anti-Ataxin 1 antibody [S768] (ab186265)
SCBT cat No: sc-8766|sc-514953|sc-366868|sc-12526|
Ataxin-1 (phospho Ser776) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Ataxin-1 (S776) Polyclonal Antibody detects endogenous levels of Ataxin-1 protein only when phosphorylated at S776.
Synthesized phospho-peptide derived from Ataxin-1 (phospho Ser776) at AA range 720-800
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
|Molecular weight|| |
Ataxin-1 (phospho Ser776) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Ataxin-1 (phospho Ser776) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ataxin-1 antibody, Spinocerebellar ataxia type 1 protein antibody
|Protein names|| |
Ataxin-1 , Spinocerebellar ataxia type 1 protein
|Protein function|| |
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism.
|Protein tissue specificity|| |
Widely expressed throughout the body.
|Involvement in disease|| |
Spinocerebellar ataxia 1 (SCA1) [MIM:164400]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by expansion of the polyglutamine tract to about 40-83 repeats, causing accumulation in neurons and exerting toxicity. .
|Protein sequence and domain|| |
The AXH domain is required for interaction with CIC. / Belongs to the ATXN1 family. / Contains 1 AXH domain.
|Protein post-translational modifications|| |
Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. / Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. / Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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