Rabbit Polyclonal Phospho-Ataxin-1 (S776) antibody (STJ90696)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Ataxin-1 (S776) antibody (STJ90696)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Ataxin-1 (phospho Ser776) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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ATXN1 antibody, ATX1 antibody, SCA1 antibody,|alternative ataxin1 antibody|Ataxin-1 antibody|ATX1 antibody|ATX1_HUMAN antibody|Atxn1 antibody|D6S504E antibody|OTTHUMP00000016065 antibody|SCA1 antibody|Spinocerebellar ataxia type 1 protein antibody|Anti-Ataxin 1 antibody [S768] (ab186265)
SCBT cat No: sc-8766|sc-514953|sc-366868|sc-12526|

 

Name

Ataxin-1 (phospho Ser776) Polyclonal Antibody

Catalogue No.

STJ90696

Reactivity

Human, Mouse

Specificity

Phospho-Ataxin-1 (S776) Polyclonal Antibody detects endogenous levels of Ataxin-1 protein only when phosphorylated at S776.

Immunogen

Synthesized phospho-peptide derived from Ataxin-1 (phospho Ser776) at AA range 720-800

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

87 kDa

Formulation

Ataxin-1 (phospho Ser776) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Ataxin-1 (phospho Ser776) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ataxin-1 antibody, Spinocerebellar ataxia type 1 protein antibody

Database links

Human UniProt/Swiss-Prot:P54253;Mouse UniPort/Swiss-Prot: P54254;Rat UniProt/Swiss-Port: Q63540;Human Entrez Gene: 6310;Mouse Entrez Gene: 20238;Rat Entrez Gene: Rn.88438

Protein names

Ataxin-1 , Spinocerebellar ataxia type 1 protein

Protein function

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism.

Protein tissue specificity

Widely expressed throughout the body.

Involvement in disease

Spinocerebellar ataxia 1 (SCA1) [MIM:164400]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by expansion of the polyglutamine tract to about 40-83 repeats, causing accumulation in neurons and exerting toxicity. .

Protein sequence and domain

The AXH domain is required for interaction with CIC. / Belongs to the ATXN1 family. / Contains 1 AXH domain.

Protein post-translational modifications

Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. / Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. / Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Signaling Intermediates>Ataxin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Ataxin-1 (phospho Ser776) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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