Rabbit Polyclonal Phospho-ATF-1 (S63) antibody (STJ90454)

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Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-ATF-1 (S63) antibody (STJ90454)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for ATF-1 (phospho Ser63) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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ATF1 antibody,|Activating transcription factor 1 antibody|ATF 1 antibody|atf1 antibody|ATF1 EWS fusion gene antibody|ATF1 FUS fusion gene antibody|ATF1_HUMAN antibody|cAMP dependent transcription factor 1 antibody|cAMP-dependent transcription factor ATF-1 antibody|Cyclic AMP dependent transcription factor ATF 1 antibody|Cyclic AMP dependent transcription factor ATF1 antibody|Cyclic AMP-dependent transcription factor ATF-1 antibody|EWS AFT1 antibody|FUS ATF 1 antibody|FUS/ATF 1 antibody|Protein TREB36 antibody|RNA binding protein activating transcription factor 1 fusion protein antibody|TREB 36 antibody|TREB36 antibody|TREB36 protein antibody|Phospho anti-ATF1 (S63) antibody [EP1591(2)Y] (ab76085)
SCBT cat No: sc-270|sc-53172|sc-243|sc-241|sc-365525|sc-187|sc-242|

 

Name

ATF-1 (phospho Ser63) Polyclonal Antibody

Catalogue No.

STJ90454

Reactivity

Human, Mouse

Specificity

Phospho-ATF-1 (S63) Polyclonal Antibody detects endogenous levels of ATF-1 protein only when phosphorylated at S63.

Immunogen

Synthesized phospho-peptide derived from ATF-1 (phospho Ser63) at AA range 1-80

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

29 kDa

Formulation

ATF-1 (phospho Ser63) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

ATF-1 (phospho Ser63) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cyclic AMP-dependent transcription factor ATF-1 antibody, cAMP-dependent transcription factor ATF-1 antibody, Activating transcription factor 1 antibody, Protein TREB36 antibody

Database links

Human UniProt/Swiss-Prot:P18846;Mouse UniPort/Swiss-Prot: P81269;Rat UniProt/Swiss-Port: F7FD47;Human Entrez Gene: 466;Mouse Entrez Gene: 11908;Rat Entrez Gene: Rn.105304

Protein names

Cyclic AMP-dependent transcription factor ATF-1 , cAMP-dependent transcription factor ATF-1 , Activating transcription factor 1 , Protein TREB36

Protein function

This protein binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Involvement in disease

Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note: The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.

Protein sequence and domain

Belongs to the bZIP family. ATF subfamily. / Contains 1 bZIP (basic-leucine zipper) domain. / Contains 1 KID (kinase-inducible) domain.

Protein post-translational modifications

Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>ATF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize ATF-1 (phospho Ser63) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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