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Rabbit Polyclonal Phospho-ATF-1 (S63) antibody (STJ90454)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for ATF-1 (phospho Ser63) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ATF1 antibody,|Activating transcription factor 1 antibody|ATF 1 antibody|atf1 antibody|ATF1 EWS fusion gene antibody|ATF1 FUS fusion gene antibody|ATF1_HUMAN antibody|cAMP dependent transcription factor 1 antibody|cAMP-dependent transcription factor ATF-1 antibody|Cyclic AMP dependent transcription factor ATF 1 antibody|Cyclic AMP dependent transcription factor ATF1 antibody|Cyclic AMP-dependent transcription factor ATF-1 antibody|EWS AFT1 antibody|FUS ATF 1 antibody|FUS/ATF 1 antibody|Protein TREB36 antibody|RNA binding protein activating transcription factor 1 fusion protein antibody|TREB 36 antibody|TREB36 antibody|TREB36 protein antibody|Phospho anti-ATF1 (S63) antibody [EP1591(2)Y] (ab76085)
SCBT cat No: sc-270|sc-53172|sc-243|sc-241|sc-365525|sc-187|sc-242|
ATF-1 (phospho Ser63) Polyclonal Antibody
|Catalogue No.|| |
Phospho-ATF-1 (S63) Polyclonal Antibody detects endogenous levels of ATF-1 protein only when phosphorylated at S63.
Synthesized phospho-peptide derived from ATF-1 (phospho Ser63) at AA range 1-80
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
ATF-1 (phospho Ser63) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ATF-1 (phospho Ser63) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cyclic AMP-dependent transcription factor ATF-1 antibody, cAMP-dependent transcription factor ATF-1 antibody, Activating transcription factor 1 antibody, Protein TREB36 antibody
|Protein names|| |
Cyclic AMP-dependent transcription factor ATF-1 , cAMP-dependent transcription factor ATF-1 , Activating transcription factor 1 , Protein TREB36
|Protein function|| |
This protein binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
|Involvement in disease|| |
Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note: The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
|Protein sequence and domain|| |
Belongs to the bZIP family. ATF subfamily. / Contains 1 bZIP (basic-leucine zipper) domain. / Contains 1 KID (kinase-inducible) domain.
|Protein post-translational modifications|| |
Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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