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Rabbit Polyclonal Phospho-ATP-citrate synthase (S455) antibody (STJ90846)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for ATP-citrate synthase (phospho Ser455) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ACLY antibody,|ACL antibody|Acly antibody|ACLY_HUMAN antibody|ATP citrate (pro-S) lyase antibody|ATP citrate lyase antibody|ATP citrate synthase antibody|ATP-citrate (pro-S-)-lyase antibody|ATP-citrate synthase antibody|ATPcitrate synthase antibody|ATPCL antibody|Citrate cleavage enzyme antibody|CLATP antibody|OTTHUMP00000164773 antibody|Anti-ATP citrate lyase antibody [EP704Y] (ab40793)
SCBT cat No: sc-30538|sc-30537|sc-368656|sc-241869|sc-271614|
ATP-citrate synthase (phospho Ser455) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Phospho-ATP-citrate synthase (S455) Polyclonal Antibody detects endogenous levels of ATP-citrate synthase protein only when phosphorylated at S455.
Synthesized phospho-peptide derived from ATP-citrate synthase (phospho Ser455) at AA range 390-470
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
ATP-citrate synthase (phospho Ser455) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ATP-citrate synthase (phospho Ser455) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ATP-citrate synthase antibody, ATP-citrate antibody, pro-S- antibody,-lyase antibody, ACL antibody, Citrate cleavage enzyme antibody
|Protein names|| |
ATP-citrate synthase , ATP-citrate , pro-S- ,-lyase , ACL , Citrate cleavage enzyme
|Protein function|| |
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. / ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. / Mg2+ / Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. Fructose 6-phosphate (F6P) is also a potent activator.
|Protein sequence and domain|| |
In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. / In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. / Contains 1 ATP-grasp domain.
|Protein post-translational modifications|| |
ISGylated. / Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2. / Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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