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Rabbit Polyclonal Phospho-Axl (Y691) antibody (STJ90939)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Axl (phospho Tyr691) Polyclonal Antibody.
Check alternative names for the antibodyExpand
AXL antibody, UFO antibody,|AI323647 antibody|Ark antibody|Axl antibody|AXL oncogene antibody|AXL receptor tyrosine kinase antibody|AXL transforming gene antibody|AXL transforming sequence/gene antibody|EC 184.108.40.206 antibody|JTK11 antibody|Oncogene AXL antibody|Tyro7 antibody|Tyrosine protein kinase receptor UFO antibody|Tyrosine-protein kinase receptor UFO antibody|UFO antibody|UFO_HUMAN antibody|Anti-Axl antibody (ab37861)
SCBT cat No: sc-166268|sc-1096|sc-20741|sc-166269|sc-1097|
Axl (phospho Tyr691) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Axl (Y691) Polyclonal Antibody detects endogenous levels of Axl protein only when phosphorylated at Y691.
Synthesized phospho-peptide derived from Axl (phospho Tyr691) at AA range 630-710
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
Axl (phospho Tyr691) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Axl (phospho Tyr691) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase receptor UFO antibody, AXL oncogene antibody
|Protein names|| |
Tyrosine-protein kinase receptor UFO , AXL oncogene
|Protein function|| |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. / (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Activated by GAS6-binding and subsequent autophosphorylation.
|Protein tissue specificity|| |
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
|Involvement in disease|| |
Note: AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. / Contains 2 fibronectin type-III domains. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion. / Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
AntibodyPlus can customize Axl (phospho Tyr691) Antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.
St John’s Laboratory Ltd.
|Product type|| |
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Antibody customer reviews & validation data - 164
Validation data ID: 164
Submission date: 2017-03-29
Rabbit Polyclonal Phospho-Axl (Y691) antibody
Product catalog No.
St John's Laboratory Ltd
Antibody specificity rating
Antibody overall rating
Its giving very low level of Phospho AXL band with lots of nonspecific band
There is no extra validation for this product yet.
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