No products in the cart.
Rabbit Polyclonal Phospho-BCL2-S70 antibody (AP0315)
Supplier: ABclonal Inc.
Recommended applications: IHC
IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-BCL2-S70 antibody.
Check alternative names for the antibodyExpand
Bcl-2 antibody; PPP1R50 antibody;
Apoptosis regulator Bcl 2 antibody|Apoptosis regulator Bcl-2 antibody|Apoptosis regulator Bcl2 antibody|AW986256 antibody|B cell CLL/lymphoma 2 antibody|B cell leukemia/lymphoma 2 antibody|Bcl-2 antibody|Bcl2 antibody|BCL2_HUMAN antibody|C430015F12Rik antibody|D630044D05Rik antibody|D830018M01Rik antibody|Leukemia/lymphoma, B-cell, 2 antibody|Oncogene B-cell leukemia 2 antibody|PPP1R50 antibody|Protein phosphatase 1, regulatory subunit 50 antibody|Anti-Bcl-2 antibody [E17] (ab32124)
SCBT cat No: sc-509|sc-56015|sc-23960|sc-130307|sc-578|sc-70411|sc-130308|sc-65392|sc-783|sc-7382|sc-492|sc-56018|sc-81002|sc-169990|sc-169989|sc-32741|sc-185|sc-13038|sc-70414|
Rabbit Polyclonal Phospho-BCL2-S70 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding S70 of human BCL2
|Recommended dilution|| |
IHC 1:50 – 1:100
|Molecular weight|| |
Phospho-BCL2-S70 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
Bcl-2 antibody; PPP1R50 antibody;
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P10415">P10415</a>
|Protein names|| |
|Protein function|| |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
|Protein tissue specificity|| |
Expressed in a variety of tissues.
|Protein sequence and domain|| |
Belongs to the Bcl-2 family. BH1 and BH2 domains are required for the interaction with BAX and for anti-apoptotic activity.; The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3.; The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.
|Protein post-translational modifications|| |
Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).; Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity.; Monoubiquitinated by PARK2, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome.
|Protein cellular localization|| |
Mitochondrion outer membrane ; Single-pass membrane protein . Nucleus membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Bcl-2/">Bcl-2</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
AntibodyPlus can customize Phospho-BCL2-S70 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: