Rabbit Polyclonal Phospho-BCL2L11-S69 antibody (AP0313)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-BCL2L11-S69 antibody (AP0313)

Supplier: ABclonal Inc.

Recommended applications: IHC,IF

Recommended dilution:

IHC 1:50 – 1:100
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BAM antibody; BIM antibody; BOD antibody;
BCL2 like 11 antibody|Bcl-2-like protein 11 antibody|BCL2 interacting mediator of cell death antibody|BCL2 like 11 (apoptosis facilitator) antibody|BCL2 like protein 11 antibody|Bcl2-interacting mediator of cell death antibody|Bcl2-L-11 antibody|Bcl2l11 antibody|BIM alpha6 antibody|BIM antibody|BIM beta6 antibody|BIM beta7 antibody|BimEL antibody|BimL antibody|BOD antibody|Anti-Bim antibody [Y36] (ab32158)

SCBT cat No: sc-130511|

Name

Rabbit Polyclonal Phospho-BCL2L11-S69 antibody

Catalogue No.

AP0313

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S69 of human BCL2L11

Host

Rabbit

Applications

IHC, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

23kDa

Formulation

Phospho-BCL2L11-S69 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BAM antibody; BIM antibody; BOD antibody;

Protein names

BAM; BIM; BOD;

Protein function

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Protein tissue specificity

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.

Protein sequence and domain

Belongs to the Bcl-2 family. The BH3 motif is required for interaction with Bcl-2 proteins and cytotoxicity.

Protein post-translational modifications

Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).; Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.

Protein cellular localization

Endomembrane system ; Peripheral membrane protein . Note=Associated with intracytoplasmic membranes.; Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of cell adherence.; Isoform BimL: Mitochondrion.; Isoform BimS: Mitochondrion.; Isoform Bim-alpha1: Mitochondrion.

Background

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Bim/">Bim</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"&gt; (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>

Note

AntibodyPlus can customize Phospho-BCL2L11-S69 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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