Rabbit Polyclonal Phospho-BCR-Y177 antibody (AP0606)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-BCR-Y177 antibody (AP0606)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ALL antibody; CML antibody; PHL antibody; BCR1 antibody; D22S11 antibody; D22S662 antibody;
ALL antibody|bcr antibody|BCR/ABL FUSION GENE, INCLUDED antibody|BCR/FGFR1 chimera protein antibody|BCR/FGFR1 FUSION GENE, INCLUDED antibody|BCR/PDGFRA FUSION GENE, INCLUDED antibody|BCR_HUMAN antibody|BCR1 antibody|Breakpoint cluster region antibody|Breakpoint cluster region protein antibody|CML antibody|D22S11 antibody|D22S662 antibody|FGFR1/BCR chimera protein antibody|PHL antibody|Renal carcinoma antigen NY-REN-26 antibody|Anti-Bcr antibody [EP535Y] (ab40779)

SCBT cat No: sc-53178|sc-103|sc-365728|sc-28375|sc-886|sc-104|sc-48422|sc-885|sc-134280|sc-134281|sc-99280|

Name

Rabbit Polyclonal Phospho-BCR-Y177 antibody

Catalogue No.

AP0606

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding Y177 of human BCR

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

143kDa

Formulation

Phospho-BCR-Y177 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ALL antibody; CML antibody; PHL antibody; BCR1 antibody; D22S11 antibody; D22S662 antibody;

Protein names

ALL; CML; PHL; BCR1; D22S11; D22S662;

Protein function

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Protein sequence and domain

Contains 1 C2 domain.; Contains 1 DH (DBL-homology) domain.; Contains 1 PH domain.; Contains 1 Rho-GAP domain. The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.; The DH domain is involved in interaction with CCPG1.

Protein post-translational modifications

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.

Protein cellular localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density .

Background

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/Bcr/">Bcr</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize Phospho-BCR-Y177 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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