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Rabbit Polyclonal Phospho-Bcr (Y177) antibody (STJ90196)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Bcr (phospho Tyr177) Polyclonal Antibody.
Check alternative names for the antibodyExpand
BCR antibody, BCR1 antibody, D22S11 antibody,|ALL antibody|bcr antibody|BCR/ABL FUSION GENE, INCLUDED antibody|BCR/FGFR1 chimera protein antibody|BCR/FGFR1 FUSION GENE, INCLUDED antibody|BCR/PDGFRA FUSION GENE, INCLUDED antibody|BCR_HUMAN antibody|BCR1 antibody|Breakpoint cluster region antibody|Breakpoint cluster region protein antibody|CML antibody|D22S11 antibody|D22S662 antibody|FGFR1/BCR chimera protein antibody|PHL antibody|Renal carcinoma antigen NY-REN-26 antibody|Anti-Bcr antibody [EP535Y] (ab40779)
SCBT cat No: sc-53178|sc-103|sc-365728|sc-28375|sc-886|sc-104|sc-48422|sc-885|sc-134280|sc-134281|sc-99280|
Bcr (phospho Tyr177) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Bcr (Y177) Polyclonal Antibody detects endogenous levels of Bcr protein only when phosphorylated at Y177.
Synthesized phospho-peptide derived from Bcr (phospho Tyr177) at AA range 120-200
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Bcr (phospho Tyr177) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Bcr (phospho Tyr177) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody
|Protein names|| |
Breakpoint cluster region protein , Renal carcinoma antigen NY-REN-26
|Protein function|| |
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. / ATP + a protein = ADP + a phosphoprotein.
|Involvement in disease|| |
Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. . Note: The gene represented in this entry is involved in disease pathogenesis.; Note: A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). .
|Protein sequence and domain|| |
The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene. / The DH domain is involved in interaction with CCPG1. / Contains 1 C2 domain. / Contains 1 DH (DBL-homology) domain. / Contains 1 PH domain. / Contains 1 Rho-GAP domain.
|Protein post-translational modifications|| |
Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
|Protein cellular localization|| |
Cell junction > synapse > postsynaptic cell membrane > postsynaptic density
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St John’s Laboratory Ltd.
|Product type|| |
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