Rabbit Polyclonal Phospho-Bcr (Y360) antibody (STJ91065)

$99.00$319.00

Reactivity: Human, Mouse, Monkey
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Bcr (Y360) antibody (STJ91065)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BCR antibody, BCR1 antibody, D22S11 antibody,|ALL antibody|bcr antibody|BCR/ABL FUSION GENE, INCLUDED antibody|BCR/FGFR1 chimera protein antibody|BCR/FGFR1 FUSION GENE, INCLUDED antibody|BCR/PDGFRA FUSION GENE, INCLUDED antibody|BCR_HUMAN antibody|BCR1 antibody|Breakpoint cluster region antibody|Breakpoint cluster region protein antibody|CML antibody|D22S11 antibody|D22S662 antibody|FGFR1/BCR chimera protein antibody|PHL antibody|Renal carcinoma antigen NY-REN-26 antibody|Anti-Bcr antibody [EP535Y] (ab40779)
SCBT cat No: sc-53178|sc-103|sc-365728|sc-28375|sc-886|sc-104|sc-48422|sc-885|sc-134280|sc-134281|sc-99280|

 

Name

Bcr (phospho Tyr360) Polyclonal Antibody

Catalogue No.

STJ91065

Reactivity

Human, Mouse, Monkey

Specificity

Phospho-Bcr (Y360) Polyclonal Antibody detects endogenous levels of Bcr protein only when phosphorylated at Y360.

Immunogen

Synthesized phospho-peptide derived from Bcr (phospho Tyr360) at AA range 300-380

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

142 kDa

Formulation

Bcr (phospho Tyr360) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Bcr (phospho Tyr360) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody

Database links

Human UniProt/Swiss-Prot:P11274;Mouse UniPort/Swiss-Prot: Q6PAJ1;Human Entrez Gene: 613;Mouse Entrez Gene: 110279;

Protein names

Breakpoint cluster region protein , Renal carcinoma antigen NY-REN-26

Protein function

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. / ATP + a protein = ADP + a phosphoprotein.

Involvement in disease

Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. . Note: The gene represented in this entry is involved in disease pathogenesis.; Note: A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). .

Protein sequence and domain

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene. / The DH domain is involved in interaction with CCPG1. / Contains 1 C2 domain. / Contains 1 DH (DBL-homology) domain. / Contains 1 PH domain. / Contains 1 Rho-GAP domain.

Protein post-translational modifications

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.

Protein cellular localization

Cell junction > synapse > postsynaptic cell membrane > postsynaptic density

Research area

All research areas>Kinases and Phosphatases>Bcr
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Bcr (phospho Tyr360) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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