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Rabbit Polyclonal Phospho-c-Myc (T358) antibody (STJ90228)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC, IP, ELISA
Recommended dilution: IHC 1:100-1:300; IP 1:200-500; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for c-Myc (phospho Thr358) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MYC antibody, BHLHE39 antibody,|AU016757 antibody|MYC_HUMAN antibody|Myc2 antibody|MYCC antibody|Myelocytomatosis oncogene antibody|Niard antibody|Nird antibody|Oncogene Myc antibody|OTTHUMP00000158589 antibody|Proto-oncogene c-Myc antibody|Protooncogene homologous to myelocytomatosis virus antibody|RNCMYC antibody|Transcription factor p64 antibody|Transcriptional regulator Myc-A antibody|V-Myc avian myelocytomatosis viral oncogene homolog antibody|v-myc myelocytomatosis viral oncogene homolog (avian) antibody|Anti-cMyc antibody [Y69] (ab32072)
SCBT cat No: sc-70469|sc-53854|sc-40|sc-47694|sc-789|sc-398624|sc-788|sc-42|sc-41|sc-373712|sc-56634|sc-764|sc-56505|sc-74349|sc-390540|sc-74351|sc-74352|sc-51053|
c-Myc (phospho Thr358) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-c-Myc (T358) Polyclonal Antibody detects endogenous levels of c-Myc protein only when phosphorylated at T358.
Synthesized phospho-peptide derived from c-Myc (phospho Thr358) at AA range 300-380
IHC, IP, ELISA
|Recommended dilution|| |
IHC 1:100-1:300; IP 1:200-500; ELISA 1:20000;
|Molecular weight|| |
c-Myc (phospho Thr358) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
c-Myc (phospho Thr358) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Myc proto-oncogene protein antibody, Class E basic helix-loop-helix protein 39 antibody, bHLHe39 antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody
|Protein names|| |
Myc proto-oncogene protein , Class E basic helix-loop-helix protein 39 , bHLHe39 , Proto-oncogene c-Myc , Transcription factor p64
|Protein function|| |
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5′-CAC[GA]TG-3′. Activates the transcription of growth-related genes.
|Involvement in disease|| |
Note: A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. .; Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. . Note: The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
|Protein sequence and domain|| |
Contains 1 bHLH (basic helix-loop-helix) domain.
|Protein post-translational modifications|| |
Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. / Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).
|Protein cellular localization|| |
Nucleus > nucleoplasm / Nucleus > nucleolus
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St John’s Laboratory Ltd.
|Product type|| |
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