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Rabbit Polyclonal Phospho-Caldesmon (S789) antibody (STJ91034)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Caldesmon (phospho Ser789) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CALD1 antibody, CAD antibody, CDM antibody,|CAD antibody|CALD 1 antibody|CALD1 antibody|CALD1_HUMAN antibody|Caldesmon 1 antibody|Caldesmon 1 Isoform 1 antibody|Caldesmon 1 Isoform 2 antibody|Caldesmon 1 Isoform 3 antibody|Caldesmon 1 Isoform 4 antibody|Caldesmon 1 Isoform 5 antibody|Caldesmon antibody|Caldesmon1 antibody|CDM antibody|H CAD antibody|HCAD antibody|L CAD antibody|LCAD antibody|MGC21352 antibody|NAG22 antibody|Anti-Caldesmon antibody [E89] (ab32330)
SCBT cat No: sc-135965|sc-271222|sc-7574|sc-58700|sc-15374|sc-7575|sc-130401|sc-390250|sc-98427|sc-48352|
Caldesmon (phospho Ser789) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Caldesmon (S789) Polyclonal Antibody detects endogenous levels of Caldesmon protein only when phosphorylated at S789.
Synthesized phospho-peptide derived from Caldesmon (phospho Ser789) at AA range 730-810
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
|Molecular weight|| |
Caldesmon (phospho Ser789) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Caldesmon (phospho Ser789) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Caldesmon antibody, CDM antibody
|Protein names|| |
Caldesmon , CDM
|Protein function|| |
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
|Protein tissue specificity|| |
High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
|Protein sequence and domain|| |
The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form. / Belongs to the caldesmon family.
|Protein post-translational modifications|| |
In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).
|Protein cellular localization|| |
Cytoplasm > cytoskeleton / Cytoplasm > myofibril
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St John’s Laboratory Ltd.
|Product type|| |
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