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Rabbit Polyclonal Phospho-Calnexin (S583) antibody (STJ90201)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Calnexin (phospho Ser583) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CANX antibody,|Calnexin antibody|CALX_HUMAN antibody|CANX antibody|CNX antibody|FLJ26570 antibody|Histocompatibility complex class I antigen binding protein p88 antibody|IP90 antibody|Major histocompatibility complex class I antigen-binding protein p88 antibody|p90 antibody|Anti-Calnexin antibody (ab22595)
SCBT cat No: sc-130059|sc-70481|sc-23954|sc-6465|sc-46669|sc-11397|sc-80645|
Calnexin (phospho Ser583) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Calnexin (S583) Polyclonal Antibody detects endogenous levels of Calnexin protein only when phosphorylated at S583.
Synthesized phospho-peptide derived from Calnexin (phospho Ser583) at AA range 520-600
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
|Molecular weight|| |
Calnexin (phospho Ser583) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Calnexin (phospho Ser583) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Calnexin antibody, IP90 antibody, Major histocompatibility complex class I antigen-binding protein p88 antibody, p90 antibody
|Protein names|| |
Calnexin , IP90 , Major histocompatibility complex class I antigen-binding protein p88 , p90
|Protein function|| |
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
|Protein sequence and domain|| |
Belongs to the calreticulin family.
|Protein post-translational modifications|| |
Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). / Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins. / Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
|Protein cellular localization|| |
Endoplasmic reticulum membrane / Single-pass type I membrane protein / Endoplasmic reticulum / Melanosome
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St John’s Laboratory Ltd.
|Product type|| |
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