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Rabbit Polyclonal Phospho-CaSR (T888) antibody (STJ90701)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for CaSR (phospho Thr888) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CASR antibody, GPRC2A antibody, PCAR1 antibody,|Ca sensing receptor antibody|Ca2+ sensing receptor 1 antibody|Ca2+ sensing receptor antibody|CAR antibody|CaSR antibody|CASR_HUMAN antibody|EIG8 antibody|Extracellular calcium sensing receptor antibody|Extracellular calcium sensing receptor [Precursor] antibody|Extracellular calcium-sensing receptor antibody|FHH antibody|FIH antibody|GPRC2A antibody|HHC antibody|HHC1 antibody|Hypocalciuric hypercalcemia 1 antibody|Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody|MGC138441 antibody|NSHPT antibody|Parathyroid Ca(2+) sensing receptor 1 antibody|Parathyroid Cell calcium sensing receptor antibody|Parathyroid Cell calcium-sensing receptor antibody|PCAR 1 antibody|PCaR1 antibody|Anti-Calcium Sensing Receptor antibody [5C10, ADD] (ab19347)
SCBT cat No: sc-47741|sc-32181|sc-33821|
CaSR (phospho Thr888) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-CaSR (T888) Polyclonal Antibody detects endogenous levels of CaSR protein only when phosphorylated at T888.
Synthesized phospho-peptide derived from CaSR (phospho Thr888) at AA range 830-910
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;
|Molecular weight|| |
CaSR (phospho Thr888) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
CaSR (phospho Thr888) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Extracellular calcium-sensing receptor antibody, CaSR antibody, Parathyroid cell calcium-sensing receptor 1 antibody, PCaR1 antibody
|Protein names|| |
Extracellular calcium-sensing receptor , CaSR , Parathyroid cell calcium-sensing receptor 1 , PCaR1
|Protein function|| |
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
|Protein tissue specificity|| |
Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
|Involvement in disease|| |
Hypocalciuric hypercalcemia, familial 1 (HHC1) [MIM:145980]: A form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hyperparathyroidism, neonatal severe (NSHPT) [MIM:239200]: A disorder characterized by severe hypercalcemia, bone demineralization, and failure to thrive usually manifesting in the first 6 months of life. If untreated, NSHPT can be a devastating neurodevelopmental disorder, which in some cases is lethal without parathyroidectomy. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hypocalcemia, autosomal dominant 1 (HYPOC1) [MIM:601198]: A disorder of mineral homeostasis characterized by blood calcium levels below normal, and low or normal serum parathyroid hormone concentrations. Disease manifestations include mild or asymptomatic hypocalcemia, paresthesias, carpopedal spasm, seizures, hypercalciuria with nephrocalcinosis or kidney stones, and ectopic and basal ganglia calcifications. Few patients manifest hypocalcemia and features of Bartter syndrome, including hypomagnesemia, hypokalemia, metabolic alkalosis, hyperreninemia, and hyperaldosteronemia. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Epilepsy, idiopathic generalized 8 (EIG8) [MIM:612899]: A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Seizure types are variable, but include myoclonic seizures, absence seizures, febrile seizures, complex partial seizures, and generalized tonic-clonic seizures. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Note: Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations.
|Protein sequence and domain|| |
Belongs to the G-protein coupled receptor 3 family.
|Protein post-translational modifications|| |
N-glycosylated. / Ubiquitinated by RNF19A; which induces proteasomal degradation.
|Protein cellular localization|| |
Cell membrane / Multi-pass membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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