Rabbit Polyclonal Phospho-CAV1-Y14 antibody (AP0320)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-CAV1-Y14 antibody (AP0320)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CGL3 antibody; PPH3 antibody; BSCL3 antibody; VIP21 antibody; MSTP085 antibody;
BSCL3 antibody|CAV antibody|CAV1 antibody|CAV1_HUMAN antibody|caveolae protein, 22 kD antibody|caveolin 1 alpha isoform antibody|caveolin 1 beta isoform antibody|Caveolin 1 caveolae protein 22kDa antibody|Caveolin-1 antibody|Caveolin1 antibody|cell growth-inhibiting protein 32 antibody|CGL3 antibody|LCCNS antibody|MSTP085 antibody|OTTHUMP00000025031 antibody|PPH3 antibody|VIP 21 antibody|VIP21 antibody|Anti-Caveolin-1 antibody (ab2910)

SCBT cat No: sc-70516|sc-53564|sc-7875|sc-894|sc-30755|sc-30754|sc-7942|sc-1858|

Name

Rabbit Polyclonal Phospho-CAV1-Y14 antibody

Catalogue No.

AP0320

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding Y14 of human CAV1

Host

Rabbit

Applications

WB, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

24kDa

Formulation

Phospho-CAV1-Y14 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CGL3 antibody; PPH3 antibody; BSCL3 antibody; VIP21 antibody; MSTP085 antibody;

Protein names

CGL3; PPH3; BSCL3; VIP21; MSTP085;

Protein function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).

Protein tissue specificity

Expressed in muscle and lung, less so in liver, brain and kidney.

Protein sequence and domain

Belongs to the caveolin family.

Protein post-translational modifications

The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.; Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.

Protein cellular localization

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft . Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

Background

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/Caveolin/">Caveolin</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"&gt; (View all antibody categories related to Signaling Intermediates)</a>

Note

AntibodyPlus can customize Phospho-CAV1-Y14 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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