Rabbit Polyclonal Phospho-Caveolin-2 (Y27) antibody (STJ90614)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Caveolin-2 (Y27) antibody (STJ90614)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Caveolin-2 (phospho Tyr27) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CAV2 antibody,|CAV antibody|CAV2 antibody|CAV2_HUMAN antibody|Caveolae protein 20 kD antibody|Caveolin 2 antibody|Caveolin 2 isoform a and b antibody|Caveolin-2 antibody|MGC12294 antibody|OTTHUMP00000025032 antibody|OTTHUMP00000195982 antibody|Phospho anti-Caveolin-2 (Y19) antibody (ab3417)
SCBT cat No: sc-30755|sc-30754|sc-7942|sc-1858|sc-5310|

 

Name

Caveolin-2 (phospho Tyr27) Polyclonal Antibody

Catalogue No.

STJ90614

Reactivity

Human

Specificity

Phospho-Caveolin-2 (Y27) Polyclonal Antibody detects endogenous levels of Caveolin-2 protein only when phosphorylated at Y27.

Immunogen

Synthesized phospho-peptide derived from Caveolin-2 (phospho Tyr27) at AA range 10-90

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

26 kDa

Formulation

Caveolin-2 (phospho Tyr27) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Caveolin-2 (phospho Tyr27) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Caveolin-2 antibody

Database links

Human UniProt/Swiss-Prot:P51636;Mouse UniPort/Swiss-Prot: Q9WVC3;Rat UniProt/Swiss-Port: Q2IBC5;Human Entrez Gene: 858;Mouse Entrez Gene: 12390;Rat Entrez Gene: Rn.81070

Protein names

Caveolin-2

Protein function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).

Protein tissue specificity

Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.

Protein sequence and domain

Belongs to the caveolin family.

Protein post-translational modifications

Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced ‘Ser-727’ phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).

Protein cellular localization

Nucleus / Cytoplasm / Golgi apparatus membrane; Peripheral membrane protein / Cell membrane; Peripheral membrane protein / Membrane > caveola; Peripheral membrane protein

Note

AntibodyPlus can customize Caveolin-2 (phospho Tyr27) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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