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Rabbit Polyclonal Phospho-Caveolin-2 (Y27) antibody (STJ90614)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Caveolin-2 (phospho Tyr27) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CAV2 antibody,|CAV antibody|CAV2 antibody|CAV2_HUMAN antibody|Caveolae protein 20 kD antibody|Caveolin 2 antibody|Caveolin 2 isoform a and b antibody|Caveolin-2 antibody|MGC12294 antibody|OTTHUMP00000025032 antibody|OTTHUMP00000195982 antibody|Phospho anti-Caveolin-2 (Y19) antibody (ab3417)
SCBT cat No: sc-30755|sc-30754|sc-7942|sc-1858|sc-5310|
Caveolin-2 (phospho Tyr27) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Caveolin-2 (Y27) Polyclonal Antibody detects endogenous levels of Caveolin-2 protein only when phosphorylated at Y27.
Synthesized phospho-peptide derived from Caveolin-2 (phospho Tyr27) at AA range 10-90
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Caveolin-2 (phospho Tyr27) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Caveolin-2 (phospho Tyr27) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
|Protein names|| |
|Protein function|| |
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
|Protein tissue specificity|| |
Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
|Protein sequence and domain|| |
Belongs to the caveolin family.
|Protein post-translational modifications|| |
Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced ‘Ser-727’ phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
|Protein cellular localization|| |
Nucleus / Cytoplasm / Golgi apparatus membrane; Peripheral membrane protein / Cell membrane; Peripheral membrane protein / Membrane > caveola; Peripheral membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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