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Rabbit Polyclonal Phospho-CCNE1-T395 antibody (AP0288)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-CCNE1-T395 antibody.
Check alternative names for the antibodyExpand
CCNE antibody|Ccne1 antibody|CCNE1_HUMAN antibody|cyclin E variant ex5del antibody|cyclin E variant ex7del antibody|Cyclin E1 antibody|Cyclin Es antibody|Cyclin Et antibody|CyclinE antibody|G1/S specific cyclin E antibody|G1/S-specific cyclin-E1 antibody|Anti-Cyclin E1 antibody [HE12] (ab3927)
SCBT cat No: sc-48420|sc-198|sc-377100|sc-20684|sc-248|sc-247|sc-481|sc-28351|
Rabbit Polyclonal Phospho-CCNE1-T395 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding T395 of human CCNE1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Phospho-CCNE1-T395 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P24864">P24864</a>
|Protein names|| |
|Protein function|| |
Essential for the control of the cell cycle at the G1/S (start) transition.
|Protein tissue specificity|| |
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
|Protein sequence and domain|| |
Belongs to the cyclin family. Cyclin E subfamily.
|Protein post-translational modifications|| |
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.; Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
|Protein cellular localization|| |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Cell-Cycle-Proteins/">Cell Cycle Proteins</a>><a href="http://antibodyplus.com/product-tag/Cyclin/">Cyclin</a><br><a href="http://antibodyplus.com/product-tag/Cell-Cycle-Proteins/"> (View all antibody categories related to Cell Cycle Proteins)</a>
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|Product type|| |
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