Rabbit Polyclonal Phospho-CD22 (Y807) antibody (STJ90608)

$99.00$319.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-CD22 (Y807) antibody (STJ90608)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for CD22 (phospho Tyr807) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CD22 antibody, SIGLEC2 antibody,|B cell receptor CD22 precursor antibody|B lymphocyte cell adhesion molecule antibody|B-cell receptor CD22 antibody|B-lymphocyte cell adhesion molecule antibody|BL CAM antibody|BL-CAM antibody|BLCAM antibody|CD 22 antibody|CD22 antibody|CD22 antigen antibody|CD22 molecule antibody|CD22 protein antibody|CD22_HUMAN antibody|Lectin 2 antibody|Leu14 antibody|Lyb8 antibody|MGC130020 antibody|sialic acid binding Ig like lectin 2 antibody|Sialic acid binding immunoglobulin like lectin 2 antibody|Sialic acid-binding Ig-like lectin 2 antibody|SIGLEC 2 antibody|Siglec-2 antibody|SIGLEC2 antibody|T cell surface antigen Leu 14 antibody|T-cell surface antigen Leu-14 antibody|Anti-CD22 antibody [2H1C4] (ab181771)
SCBT cat No: sc-53031|sc-53032|

 

Name

CD22 (phospho Tyr807) Polyclonal Antibody

Catalogue No.

STJ90608

Reactivity

Human

Specificity

Phospho-CD22 (Y807) Polyclonal Antibody detects endogenous levels of CD22 protein only when phosphorylated at Y807.

Immunogen

Synthesized phospho-peptide derived from CD22 (phospho Tyr807) at AA range 750-830

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

95 kDa

Formulation

CD22 (phospho Tyr807) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

CD22 (phospho Tyr807) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

B-cell receptor CD22 antibody, B-lymphocyte cell adhesion molecule antibody, BL-CAM antibody, Sialic acid-binding Ig-like lectin 2 antibody, Siglec-2 antibody, T-cell surface antigen Leu-14 antibody, CD antigen CD22 antibody

Database links

Human UniProt/Swiss-Prot:P20273;Mouse UniPort/Swiss-Prot: P35329;Rat UniProt/Swiss-Port: D3ZD88;Human Entrez Gene: 933;Mouse Entrez Gene: 12483;Rat Entrez Gene: Rn.25921

Protein names

B-cell receptor CD22 , B-lymphocyte cell adhesion molecule , BL-CAM , Sialic acid-binding Ig-like lectin 2 , Siglec-2 , T-cell surface antigen Leu-14 , CD antigen CD22

Protein function

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Protein tissue specificity

B-lymphocytes.

Protein sequence and domain

Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. / Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. / Contains 6 Ig-like C2-type (immunoglobulin-like) domains. / Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein post-translational modifications

Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. / Phosphorylated on tyrosine residues by LYN.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein

Research area

All research areas>Lymphocyte Signaling>CD22
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD22 (phospho Tyr807) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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