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Rabbit Polyclonal Phospho-CD32 (Y292) antibody (STJ90485)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for CD32 (phospho Tyr292) Polyclonal Antibody.
Check alternative names for the antibodyExpand
FCGR2B antibody, CD32 antibody, FCG2 antibody, IGFR2 antibody,||
SCBT cat No: To be updated
CD32 (phospho Tyr292) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-CD32 (Y292) Polyclonal Antibody detects endogenous levels of CD32 protein only when phosphorylated at Y292.
Synthesized phospho-peptide derived from CD32 (phospho Tyr292) at AA range 230-310
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
CD32 (phospho Tyr292) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
CD32 (phospho Tyr292) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Low affinity immunoglobulin gamma Fc region receptor II-b antibody, IgG Fc receptor II-b antibody, CDw32 antibody, Fc-gamma RII-b antibody, Fc-gamma-RIIb antibody, FcRII-b antibody, CD antigen CD32 antibody
|Protein names|| |
Low affinity immunoglobulin gamma Fc region receptor II-b , IgG Fc receptor II-b , CDw32 , Fc-gamma RII-b , Fc-gamma-RIIb , FcRII-b , CD antigen CD32
|Protein function|| |
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
|Protein tissue specificity|| |
Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
|Involvement in disease|| |
Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
|Protein post-translational modifications|| |
Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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