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Rabbit Polyclonal Phospho-Cdc25A (S124) antibody (STJ90511)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cdc25A (phospho Ser124) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CDC25A antibody,|Cdc 25a antibody|CDC25A antibody|CDC25A2 antibody|CDC25A2 CAG isoform antibody|Cell division cycle 25 homolog A (S. pombe) antibody|Cell division cycle 25A antibody|Cell division cycle 25A isoform a antibody|Cell division cycle 25A isoform b antibody|D9Ertd393e antibody|Dual specificity phosphatase Cdc25A antibody|M phase inducer phosphatase 1 antibody|M-phase inducer phosphatase 1 antibody|MGC115549 antibody|MPIP1_HUMAN antibody|Anti-Cdc25A antibody [DCS-120 + DCS-121] (ab2357)
SCBT cat No: sc-97|sc-70823|sc-70824|sc-56263|sc-56264|sc-65503|sc-65505|sc-7389|sc-7157|sc-6947|sc-56265|sc-70825|sc-326|
Cdc25A (phospho Ser124) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Cdc25A (S124) Polyclonal Antibody detects endogenous levels of Cdc25A protein only when phosphorylated at S124.
Synthesized phospho-peptide derived from Cdc25A (phospho Ser124) at AA range 60-140
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
Cdc25A (phospho Ser124) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cdc25A (phospho Ser124) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
M-phase inducer phosphatase 1 antibody, Dual specificity phosphatase Cdc25A antibody
|Protein names|| |
M-phase inducer phosphatase 1 , Dual specificity phosphatase Cdc25A
|Protein function|| |
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. / Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. / Stimulated by B-type cyclins. Stimulated by PIM1-mediated phosphorylation.
|Protein sequence and domain|| |
The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction. / Belongs to the MPI phosphatase family. / Contains 1 rhodanese domain.
|Protein post-translational modifications|| |
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation. / Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization.
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St John’s Laboratory Ltd.
|Product type|| |
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