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Rabbit Polyclonal Phospho-Cdc25b-S149 antibody (AP0322)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
AI604853 antibody|Cdc 25B antibody|Cdc25b antibody|CDC25HU2 antibody|Cdc25m2 antibody|Cell division cycle 25 homolog B antibody|Cell division cycle 25B antibody|Cell division cycle 25B isoform 1 antibody|Cell division cycle 25B isoform 2 antibody|Cell division cycle 25B isoform 3 antibody|Cell division cycle 25B isoform 4 antibody|Cell division cycle 25B isoform 5 antibody|Dual specificity phosphatase Cdc25B antibody|EC 22.214.171.124 antibody|M phase inducer phosphatase 2 antibody|M-phase inducer phosphatase 2 antibody|MPIP2_HUMAN antibody|Phospho anti-Cdc25B (S323) antibody (ab53103)
SCBT cat No: sc-70825|sc-326|sc-56266|sc-65504|sc-6948|sc-5619|sc-56357|sc-327|
Rabbit Polyclonal Phospho-Cdc25b-S149 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding S149 of human Cdc25b
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Phospho-Cdc25b-S149 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P30305">P30305</a>
|Protein names|| |
|Protein function|| |
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
|Protein sequence and domain|| |
Belongs to the MPI phosphatase family.; Contains 1 rhodanese domain.
|Protein post-translational modifications|| |
Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
|Protein cellular localization|| |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole .
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Cell-Cycle-Proteins/">Cell Cycle Proteins</a>><a href="http://antibodyplus.com/product-tag/Cdc/">Cdc</a><br><a href="http://antibodyplus.com/product-tag/Cell-Cycle-Proteins/"> (View all antibody categories related to Cell Cycle Proteins)</a>
AntibodyPlus can customize Phospho-Cdc25b-S149 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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